Zogulitsa

L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, ndi Sodium Ascorbyl Phosphate amagwira ntchito muzodzoladzola zodzikongoletsera makamaka ngati antioxidants.Ascorbic Acid nthawi zambiri amatchedwa Vitamini C. Ascorbic Acid amagwiritsidwa ntchito ngati antioxidant ndi pH adjuster mumitundu yambiri yodzikongoletsera, yoposa 3/4 yomwe inali utoto wa tsitsi ndi mitundu pazigawo zapakati pa 0.3% ndi 0.6%.Pazogwiritsa ntchito zina, zomwe zanenedwazo zinali zotsika kwambiri (<0.01%) kapena mu 5% mpaka 10%.Calcium Ascorbate ndi Magnesium Ascorbate amafotokozedwa ngati antioxidants ndi zokometsera khungu - zosiyanasiyana kuti zigwiritsidwe ntchito mu zodzoladzola, koma sizikugwiritsidwa ntchito pano.Sodium Ascorbyl Phosphate imagwira ntchito ngati antioxidant muzodzikongoletsera ndipo imagwiritsidwa ntchito pazambiri zoyambira 0.01% mpaka 3%.Magnesium Ascorbyl Phosphate imagwira ntchito ngati antioxidant mu zodzoladzola ndipo idanenedwa kuti ikugwiritsidwa ntchito pazambiri kuyambira 0.001% mpaka 3%.Sodium Ascorbate imagwiranso ntchito ngati antioxidant mu zodzoladzola pamiyeso kuchokera ku 0.0003% mpaka 0.3%.Zosakaniza zofananira (Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate, Erythorbic Acid, ndi Sodium Erythorbate) zidawunikiridwa kale ndi Cosmetic Ingredient Review (CIR) Expert Panel ndipo zidapezeka kuti "ndi zotetezeka kuti zigwiritsidwe ntchito ngati zodzikongoletsera pazabwino zomwe zikuchitika pano. kugwiritsa ntchito."Ascorbic Acid ndi chinthu chomwe chimadziwika kuti ndi chotetezeka (GRAS) kuti chigwiritsidwe ntchito ngati mankhwala osungira muzakudya komanso ngati chowonjezera komanso / kapena zakudya zowonjezera.Calcium Ascorbate ndi Sodium Ascorbate amalembedwa ngati zinthu za GRAS kuti zigwiritsidwe ntchito ngati zosungira mankhwala.L-Ascorbic Acid imapangidwa mosavuta komanso mosinthika kukhala L-dehydroascorbic acid ndipo mitundu yonseyi imakhala yofanana m'thupi.Mapiritsi a Ascorbic Acid kupyola pakhungu lonse la mbewa anali 3.43 +/- 0.74 microg/cm(2)/h ndi 33.2 +/- 5.2 microg/cm(2)/h.Kafukufuku wapakamwa komanso wolera anawonetsa kawopsedwe pang'ono.Ascorbic Acid ndi Sodium Ascorbate adakhala ngati inhibitor ya nitrosation m'maphunziro angapo azakudya ndi zodzikongoletsera.Palibe zizindikiro zachipatala zokhudzana ndi pawiri kapena zowopsa kapena zazing'ono kwambiri zomwe zidawonedwa mu mbewa, makoswe, kapena nkhumba m'maphunziro akanthawi kochepa.Nkhumba zamphongo zamphongo zimadyetsera zakudya zoyambira komanso zopatsa 250 mg Ascorbic Acid pakamwa kwa milungu 20 zinali ndi hemoglobin yofanana, shuga wamagazi, chitsulo cha seramu, chitsulo cha chiwindi, ndi milingo ya glycogen ya chiwindi poyerekeza ndi kuwongolera.Makoswe aamuna ndi aakazi a F344/N ndi B6C3F (1) mbewa adadyetsedwa zakudya zomwe zimakhala ndi 100,000 ppm Ascorbic Acid kwa milungu 13 yokhala ndi kawopsedwe kakang'ono.Kafukufuku wopatsa thanzi wa ascorbic Acid adawonetsa zowopsa pamilingo yopitilira 25 mg / kg kulemera kwa thupi (bw) mu makoswe ndi nkhumba.Magulu a makoswe aamuna ndi aakazi omwe amapatsidwa Mlingo watsiku ndi tsiku mpaka 2000 mg/kg bw Ascorbic Acid kwa zaka 2 analibe zotupa zakupha zazikulu kapena zazing'ono.Makoswe omwe anapatsidwa Ascorbic Acid subcutaneous ndi mtsempha watsiku ndi tsiku (500 kwa 1000 mg / kg bw) kwa masiku 7 analibe kusintha kwa chilakolako, kulemera, ndi khalidwe lachidziwitso;ndi histological kufufuza ziwalo zosiyanasiyana anasonyeza palibe kusintha.Ascorbic Acid anali photoprotectant pamene ankagwiritsidwa ntchito pa mbewa ndi khungu la nkhumba pamaso pa cheza cha ultraviolet (UV).Kuletsa kwa UV-induced kuponderezedwa kwa kukhudzana ndi hypersensitivity kunadziwikanso.Magnesium Ascorbyl Phosphate kasamalidwe atangodziwonetsa mu mbewa zopanda tsitsi adachedwetsa kupanga chotupa chapakhungu komanso hyperplasia yoyambitsidwa ndi cheza cha UV.Makoswe apakati ndi makoswe amapatsidwa mlingo wa tsiku ndi tsiku wa Ascorbic Acid mpaka 1000 mg / kg bw popanda zizindikiro za akuluakulu-poizoni, teratogenic, kapena fetotoxic zotsatira.Ascorbic Acid ndi Sodium Ascorbate sanali genotoxic m'machitidwe angapo oyesa mabakiteriya ndi mammalian, ogwirizana ndi antioxidant katundu wa mankhwalawa.Pamaso pa machitidwe ena a enzyme kapena ayoni azitsulo, umboni wa genotoxicity udawoneka.National Toxicology Programme (NTP) idachita kafukufuku wazaka 2 wa oral carcinogenesis bioassay ya Ascorbic Acid (25,000 ndi 50,000 ppm) mu makoswe a F344/N ndi B6C3F (1) mbewa.Ascorbic Acid sanali carcinogenic mu kugonana kulikonse kwa makoswe ndi mbewa.Kuletsa kwa carcinogenesis ndi kukula kwa chotupa chokhudzana ndi ascorbic Acid antioxidant properties zanenedwa.Sodium Ascorbate yasonyezedwa kuti imalimbikitsa chitukuko cha khansa ya mkodzo mu maphunziro a magawo awiri a carcinogenesis.Kugwiritsa ntchito khungu kwa ascorbic Acid kwa odwala omwe ali ndi radiation dermatitis ndi omwe adawotcha sikunakhale ndi zotsatirapo zoyipa.Ascorbic Acid anali photoprotectant m'maphunziro azachipatala a UV pamiyeso yopitilira muyeso wocheperako wa erythema (MED).Kirimu wosawoneka bwino wokhala ndi 5% Ascorbic Acid sichinapangitse chidwi cha dermal mu maphunziro a anthu 103.Chida chomwe chili ndi 10% Ascorbic Acid sichinali chowopsa mu 4-day minicumulative patch assay pakhungu la munthu ndipo chithandizo cha nkhope chokhala ndi 10% Ascorbic Acid sichinali cholumikizira cholumikizira pakuyesa kukulitsa kwa anthu 26.Chifukwa cha mawonekedwe ndi magwiridwe antchito a zosakaniza izi, Gululi likukhulupirira kuti zomwe zili pagawo limodzi zitha kuperekedwa kwa onse.Gulu la Katswiri linanena kuti anapeza kuti Ascorbic Acid inali genotoxic m'machitidwe oyesera ochepawa chifukwa cha kukhalapo kwa mankhwala ena, mwachitsanzo, zitsulo, kapena machitidwe ena a enzyme, omwe amasintha bwino zochita za antioxidant za Ascorbic Acid kukhala pro-oxidant.Pamene Ascorbic Acid imagwira ntchito ngati antioxidant, gululo linanena kuti Ascorbic Acid si genotoxic.Kuchirikiza lingaliro limeneli kunali maphunziro a carcinogenicity ochitidwa ndi NTP, omwe sanasonyeze umboni wa carcinogenicity.Ascorbic Acid adapezeka kuti amalepheretsa zokolola za nitrosamine m'machitidwe angapo oyesera.Gululi lidawunikiranso maphunziro omwe Sodium Ascorbate idachita ngati chotupa mu nyama.Zotsatirazi zimawonedwa kuti zikugwirizana ndi kuchuluka kwa ayoni a sodium ndi pH ya mkodzo mu nyama zoyesedwa.Zotsatira zofananazi zidawonedwa ndi sodium bicarbonate.Chifukwa chodera nkhawa kuti ma ayoni achitsulo ena angaphatikizidwe ndi zinthuzi kuti apange zinthu zopatsa mphamvu, gululi lidachenjeza opanga ma formula kuti atsimikize kuti zosakanizazi zimagwira ntchito ngati ma antioxidants mu zodzoladzola.Gululi limakhulupirira kuti zochitika zachipatala zomwe Ascorbic Acid idagwiritsidwa ntchito pakhungu lowonongeka popanda zotsatira zoyipa komanso kuyesa kwa chigamba chobwereza (RIPT) pogwiritsa ntchito 5% Ascorbic Acid ndi zotsatira zoyipa kumathandizira kupeza kuti gulu ili la zosakaniza silimapereka chiopsezo chokhudzidwa ndi khungu.Deta iyi komanso kusakhalapo kwa malipoti m'mabuku azachipatala a Ascorbic Acid sensitization imathandizira kwambiri chitetezo chazinthu izi.