Zogulitsa

M'mbuyomu tidakhazikitsa chikhalidwe cha nthawi yayitali, cha 3-dimensional of organoids kuchokera kumatumbo a mbewa (matumbo, m'mimba, kapamba, ndi chiwindi) ndi matumbo amunthu ndi kapamba.Apa tikufotokoza zinthu zofunika kwa nthawi yaitali 3-dimensional chikhalidwe cha anthu chapamimba tsinde maselo.Tekinolojeyi ingagwiritsidwe ntchito pophunzira kuyankha kwa epithelial ku matenda a Helicobacter pylori.Tinapanga organoids kuchokera ku zitsanzo za opaleshoni ya chapamimba chamunthu.Mikhalidwe ya chikhalidwe idapangidwa kutengera zomwe za m'mimba ya mbewa ndi m'matumbo amunthu.Tidagwiritsa ntchito ma microinjection kuti tipatsire ma organoids ndi H pylori.Mayankho a epithelial adayesedwa pogwiritsa ntchito ma microarray ndi kuchuluka kwa polymerase chain reaction analyses.Tidapanga ma cell kuchokera m'matumbo athanzi am'mimba, ma cell amtundu umodzi, kapena zotupa.Organoids adasunga mawonekedwe ambiri a minofu yawo kutengera mbiri yawo, mawonekedwe a zolembera, ndi euploidy.Ma Organoids ochokera ku minofu yathanzi adawonetsa zolembera za mizere 4 yam'mimba ndikudzipanga tokha kukhala madera a gland ndi dzenje.Atha kuloza kuti afotokoze mwachindunji mizere ya chapamimba, kapena dzenje lapamimba, powonjezera nicotinamide ndi kuchotsa kwa WNT.Ngakhale kuti mizere ya m'mimba ya m'mimba inali ndi zotsatira zochepa chabe za matenda a bakiteriya, mizere ya m'mimba ya m'mimba inachititsa kuti pakhale kutupa kwakukulu.Dongosololi litha kugwiritsidwa ntchito pophunzira matenda a H pylori ndi matenda ena am'mimba.Copyright © 2015 AGA Institute.Lofalitsidwa ndi Elsevier Inc. Ufulu wonse ndiwotetezedwa.