Kupatsidwa folic Acid Cas: 59-30-3 99%
| Nambala ya Catalog | XD90435 |
| Dzina lazogulitsa | Folic Acid |
| CAS | 59-30-3 |
| Molecular Formula | C19H19N7O6 |
| Kulemera kwa Maselo | 441.40 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29362900 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Yellow kapena lalanje crystalline ufa |
| Kuyesa | 99% |
| Madzi | 5.0 - 8.5% |
| Chromatographic chiyero | <2.0% |
| Kusungunuka | Pafupifupi osasungunuka m'madzi ndi zosungunulira zambiri za organic.Amasungunuka mu ma asidi osungunuka komanso muzitsulo zamchere |
| Zotsalira pa Ignition | <0.3% |
Mu phunziro ili, thermosensitive ndi folate functionalized poly(ethylene oxide) -b-poly(propylene oxide) -b-poly(ethylene oxide) -ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer anali. zopangidwa.Mapangidwe ndi kulemera kwa maselo a copolymer adatsimikiziridwa ndi 1H NMR, FT-IR ndi GPC, motsatira.Kutentha kwapadera kwapadera (LCST) kwa copolymer kunali madigiri 39.8 C. Pogwiritsa ntchito doxorubicin (DOX) monga mankhwala achitsanzo, ma cell a folate omwe amatsogoleredwa ndi DOX adapangidwanso pa copolymer.Ma micelles opanda kanthu komanso odzaza ndi DOX onse amawonetsa mawonekedwe ozungulira ndipo ma diameter awo anali 35 nm ndi 50 nm, motsatana.Makhalidwe otulutsidwa mu vitro a DOX-loaded micelles anali odalira kutentha ndipo mlingo wotulutsidwa wa DOX pa 42 ° C (pamwamba pa LCST) unali wofulumira kuposa 37 ° C (pansi pa LCST).Kuphatikiza apo, ma cytotoxicity assays a ma cell aulere a DOX ndi DOX odzaza ma cell a khansa ya khomo lachiberekero HeLa ndi ma cell a khansa ya m'mapapo ya anthu A549 adawonetsa kuti folate imachulukitsa kutengeka kwa ma cell m'maselo omwe akuwunikiridwa omwe amawonetsa kwambiri ma folate receptors.
