N, N'-Methylenebisacrylamide Cas: 110-26-9 98% ufa woyera
| Nambala ya Catalog | XD90231 |
| Dzina lazogulitsa | N, N'-Methylenebisacrylamide |
| CAS | 110-26-9 |
| Molecular Formula | C7H10N2O2 |
| Kulemera kwa Maselo | 154.1665 |
| Zambiri Zosungira | 2 mpaka 8 ° C |
| Harmonize Tariff Code | 29241900 |
Mafotokozedwe a Zamalonda
| Kuyesa | > 98% |
| Madzi osasungunuka | <0.5% |
| Maonekedwe | White ufa |
| Inorganic sulfates | <0.5% |
| Zogwiritsidwa ntchito pofufuza zokha, osati za anthu | ntchito zofufuza zokha, osati za anthu |
Udindo wofunikira wa tumor-associated fibroblasts (TAF) pakukula kwa khansa tsopano ukuwonekera mu khansa yosakhala yaying'ono ya m'mapapo (NSCLC).Komabe, njira zochiritsira zolimbana ndi ma TAF ndizochepa chifukwa chosowa kumvetsetsa munjira zinazake zomwe zimatengera kudzikundikira kwawo.Apa, makina (ie, matrix rigidity) ndi ma mitogenic cues osungunuka omwe amayendetsa kusonkhanitsa kwa TAFs kuchokera kumagulu akuluakulu a NSCLC: adenocarcinoma (ADC) ndi squamous cell carcinoma (SCC) adagawidwa.Ma Fibroblasts adapangidwa pagawo lopangidwa kuti liwonetse kuuma kwabwinobwino kapena chotupa pamagawo osiyanasiyana a seramu, ndipo njira zowongolera zidadziwika.Poyang'anira ma fibroblasts kuchokera ku minofu yopanda vuto, kuuma kwa matrix kokha kumawonjezera kuchuluka kwa fibroblast, ndipo mphamvu yamakinayi inali yayikulu kapena yofananira ndi ya kukula kwa sungunuka mpaka 0.5% seramu.Zolimbikitsa za kukhazikika kwa matrix zidayendetsedwa ndi β1 integrin mechano-sensing kudzera mu FAK (pY397), ndipo zidalumikizidwa ndi kukwera kwa posttranscriptally motsogozedwa ndi β1 integrin expression.Dera lomaliza la mechano-regulatory dera lidawonedwanso mu TAFs koma mwanjira yodziwika bwino, chifukwa ma SCC-TAF adawonetsa ma FAK apamwamba (pY397), mawu a β1, ndi ERK1/2 (pT202/Y204) kuposa ma ADC-TAF.Kuphatikiza apo, kuuma kwa matrix kudapangitsa kuti TAF ichuluke mu SCC-TAFs (> 50%) poyerekeza ndi ma ADC-TAF (10% -20%).Mosiyana ndi izi, ma SCC-TAF anali odetsedwa kwambiri ndi seramu, pomwe ma ADC-TAF adayankha kukhathamira kwakukulu kwa seramu kokha.Zotsatirazi zimapereka umboni woyamba wa kuwongolera kwapang'onopang'ono kwa NSCLC-TAF kudzikundikira.Kuphatikiza apo, deta iyi imathandizira kuti mankhwala omwe akufuna kubwezeretsa kusungunuka kwa mapapu ndi/kapena β1 integrin-dependent mechano regulation akhoza kukhala othandiza motsutsana ndi SCC-TAFs, pamene kulepheretsa kukula kwa stromal factor factor kungakhale kothandiza motsutsana ndi ADC-TAFs. Kuchulukana kwachilendo kwa ma fibroblasts othandizira chotupa m'magulu awiri akuluakulu a khansa ya m'mapapo, zomwe zingathandize kupanga chithandizo chamunthu payekha motsutsana ndi maselowa.
