Zogulitsa

Tafufuza za kukhazikika kwa thupi la amorphous curcumin dispersions ndi ntchito ya curcumin-polymer intermolecular interactions pochedwetsa kukongola kwa crystallization.Curcumin ndi gawo losangalatsa lachitsanzo chifukwa limapanga ma intra and intermolecular hydrogen bond mu kristalo.A structural zosiyanasiyana amorphous dispersion ma polima anafufuzidwa;poly(vinylpyrrolidone), Eudragit E100, carboxymethyl cellulose acetate butyrate, hydroxypropyl methyl cellulose (HPMC) ndi HPMC-acetate succinate.Mid-infrared spectroscopy idagwiritsidwa ntchito kudziwa ndikuwerengera kuchuluka kwa kuyanjana kwa curcumin-polymer.Kukhazikika kwathupi pansi pazikhalidwe zosiyanasiyana zachilengedwe kumayang'aniridwa ndi ufa wa X-ray diffraction.Kukhazikika kwa mankhwala a Curcumin kumayang'aniridwa ndi UV-Vis spectroscopy.Kudzipatula kwa amorphous curcumin okhazikika kunali kovuta pakalibe ma polima.Ma polima adatsimikizira kukhala othandiza kwa curcumin crystallization inhibitors omwe amathandizira kupanga ma amorphous olimba dispersions;Komabe, ma polima anasonyeza luso osiyana kwambiri ziletsa crystallization pa kusungidwa kwa nthawi yaitali.Curcumin intramolecular hydrogen bonding inachepetsa kukula kwa hydrogen kugwirizana kwake ndi ma polima;chifukwa chake ma polima ambiri sanali othandiza kwambiri crystallization inhibitors.Pazonse, ma polima adawonetsa kuti ndi ma crystallization inhibitors, koma kuletsa kunali kochepa chifukwa cha kugwirizana kwa intramolecular hydrogen mu curcumin, zomwe zimabweretsa kuchepa kwa kuthekera kwa ma polima kuti agwirizane pamlingo wa maselo.