Zogulitsa

Kuyanjana pakati pa mankhwala a antidiabetic, Metformin ndi ng'ombe thymus DNA (CT-DNA) mu (50mM Tris-HCl) buffer adaphunziridwa ndi UV-Visible mayamwidwe, fluorescence, CD spectroscopy ndi viscosity miyeso.M'maphunziro a fluorimetric, enthalpy ndi entropy ya zomwe zimachitika pakati pa mankhwala ndi CT-DNA zinasonyeza kuti zomwe zimachitika ndi exothermic (ΔH = -35.4522 kJ mol (-1); ΔS = -49.9523 J mol (-1) K (-1) )).Kafukufuku wampikisano womangiriza adawonetsa kuti mankhwalawa amatha kumasula Hoechst 33258 kwathunthu.Zovutazo zidawonetsa mayamwidwe a hyperchromism mu mawonekedwe ake a UV-Vis okhala ndi DNA.Kumangirira kosalekeza, K(b), kopezedwa kuchokera ku maphunziro a UV-Vis kuyamwa kunali 8.3×10(4)M(-1).Kuphatikiza apo, kusintha kwa mawonekedwe a CD pamaso pa mankhwalawa kukuwonetsa kukhazikika kwa mawonekedwe amanja a B a CT-DNA.Pomaliza, kuyeza mamasukidwe akayendedwe kunavumbula kuti kumangika kwa zovutazo ndi CT-DNA zitha kukhala zomangiriza pamwamba, makamaka chifukwa chomangirira poyambira.Copyright © 2012 Elsevier BV Ufulu wonse ndi wotetezedwa.