Zogulitsa

Poizoni wa Ricin (RT) ndi poizoni wachiwiri wakupha wodziwika;idasankhidwa ndi CDC ngati wosankhidwa.RT imapangidwa ndi chomera cha nyemba za castor;pafupifupi matani 50,000 a RT amapangidwa chaka chilichonse ngati mafuta a castor.RT ili ndi ma subunits awiri, unyolo wa ribotoxic A (RTA) ndi galactose-binding B chain (RTB).RT imamangiriza ku maselo onse amtundu wa mammalian ndipo kamodzi ikalowetsedwa mkati, RTA imodzi imayambitsa ma ribosomes onse mu selo.Imayendetsedwa ngati aerosol, RT imayambitsa kuwonongeka kwamapapu mwachangu komanso fibrosis yotsatiridwa ndi imfa.Palibe katemera wovomerezeka wa Food and Drug Administration ndipo chithandizo chimagwira ntchito m'maola angapo oyambirira mutatha kuwonekera.Tapanga katemera wina wa RTA yemwe ali ndi masinthidwe awiri a V76M/Y80A (RiVax).Puloteniyi imawonetsedwa mu Escherichia coli ndipo ilibe poizoni komanso imateteza thupi ku mbewa, akalulu, ndi anthu.Pamene mbewa za katemera zimatsutsidwa ndi jakisoni, aerosolized, kapena pakamwa (gavaged) RT, zimatetezedwa kwathunthu.Tsopano tapanga makina otenthetsera, a aluminium-adjuvant okhala ndi RiVax ndikuyesa mu rhesus macaques.Pambuyo pa jakisoni atatu, nyamazo zidapanga ma antibodies omwe adawateteza ku mlingo wakupha wa RT.Ma antibodies awa adachepetsa RT ndikupikisana mosiyanasiyana ndi gulu la ma antigen omwe amadziwika kuti amazindikira ma epitopes pa RTA yakubadwa.Zotsatira za mpikisano wa antibody zitha kuyimira siginecha ya chitetezo chamthupi.Chofunika kwambiri, siginecha yomweyo idawonedwa pogwiritsa ntchito sera kuchokera kwa anthu omwe ali ndi katemera wa RiVax.