Zogulitsa

Ischemic stroke yawonetsedwa kuti imayambitsa hypermetabolism ya shuga mu ischemic penumbra.Zambiri zoyesa komanso zamankhwala zikuwonetsa kuti infarct-related systemic hyperglycemia ndi chandamale chochizira chomwe chingathe kudwala sitiroko yowopsa.Komabe, maphunziro azachipatala omwe amayang'ana kuwongolera kwa glucose mu sitiroko yowopsa sanasinthe magwiridwe antchito kapena kuchepetsa kufa.Chifukwa chake, maphunziro owonjezera okhudza kagayidwe ka glucose muubongo wa ischemic ndiwotsimikizika.Tidagwiritsa ntchito makoswe a sitiroko omwe amasunga chikole.Zinyamazo zinawunikidwa ndi [2-(18)F] -2-fluoro-2-deoxy-d-glucose positron emission tomography kapena maginito a resonance imaging panthawi ya 90-minute occlusion of the middle brain artery and during 60 minutes after reperfusion.Zotsatira zinali zogwirizana ndi kuyerekezera kwa maginito a kutuluka kwa magazi muubongo, kufalikira kwa madzi, kupanga lactate, ndi mbiri ya histological pa kufa kwa cell komanso kuwonongeka kwa chotchinga cha magazi muubongo. -kutengeka kwa deoxy-d-glucose mkati mwa ma ischemic re gions omwe amagonja ku infarction komanso m'chigawo cha peri-infarct.Kujambula kwa maginito a maginito kunavumbula kuwonongeka kwa magazi ku milingo ya ischemic mu infarct komanso kuchepa kwa magazi muubongo kudera la peri-infarct.Magnetic resonance spectroscopy adawulula lactate m'chigawo cha ischemic komanso kusowa kwa lactate m'chigawo cha peri-infarct.Kusanthula kwa Immunohistochemical kunavumbulutsa apoptosis ndi kuwonongeka kwa chotchinga chamagazi ndi ubongo mkati mwa infarct. Zosowa za ischemic ndi hypoperfused brain tissues, ndipo zimachitika pansi pa anaerobic ndi aerobic mikhalidwe yoyesedwa ndi kupanga lactate komweko.Zokhudzana ndi infarct systemic hyperglycemia zitha kuthandiza kuperekera shuga ku ubongo wa ischemic.Kuwongolera kwa glycemic ndi chithandizo cha insulin kumatha kusokoneza njirayi.