Zogulitsa

Interferon-induced transmembrane protein 1 (IFITM1) ndi amodzi mwa mamembala a banja la mapuloteni a transmembrane omwe amapangidwa ndi interferon.Mu phunziro ili, tinanena kuti mawu okwera a IFITM1 mu khansa yamtundu wa anthu (CRC) amagwirizana kwambiri ndi CRC lymph node ndi mtunda wa metastasis komanso siteji yapamwamba kwambiri yachipatala.Chofunika kwambiri, mawu okwezeka a IFITM1 ndi gawo lodziyimira pawokha la kupulumuka kosauka.Kuti tifufuze machitidwe a maselo, tinawonetsa kuti kufotokoza mopitirira muyeso kwa IFITM1 m'maselo a CRC amalimbikitsidwa, pamene kugogoda kwa mawu a IFITM1 kumaletsedwa, kusuntha kwa selo / kuukira ndi tumorigenicity mu vitro.Kuphatikiza apo, tidazindikira Caveolin-1 (CAV1) ngati chandamale chapansi pa IFITM1-induced cell invasion, monga kugwetsa kwa CAV1 kuchotsedwa kwa siIFITM1 kuletsa kuletsa kufalikira kwa ma cell m'maselo a CRC.Kuonjezera apo, mu gulu la CRC la odwala 229, mawu a IFITM1 osagwirizana ndi mawu a CAV1.Zotsatirazi zikusonyeza kuti IFITM1 imalimbikitsa kutengeka kwa ma cell a CRC, ndipo ndizomwe zingatheke kuti zikhale chizindikiro komanso chithandizo cha CRC.