DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS: 28718-90-3 99% Yellow powder
| Nambala ya Catalog | XD90505 |
| Dzina lazogulitsa | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Molecular Formula | Chithunzi cha C16H15N5 · 2HCl |
| Kulemera kwa Maselo | 350.25 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 2933998090 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Yellow powder |
| Kuyesa | 99% mphindi |
| Zogwiritsidwa ntchito pofufuza zokha, osati za anthu | Kafukufuku amagwiritsa ntchito kokha, osati kugwiritsidwa ntchito ndi anthu |
Melatonin imakhudzidwa ndi ntchito zambiri zakuthupi, ndipo imakhala ndi zotsatira zosiyana pa apoptosis m'maselo abwinobwino komanso a khansa.Komabe, limagwirira ntchito zake za antitumor sizimamveka bwino.Mu kafukufukuyu, tikuwonetsa kuti melatonin imakulitsa apoptosis yopangidwa ndi tunicamycin m'maselo a khansa ya m'mawere a MDA-MB-231.Melatonin up-regulates pro-apoptotic protein Bim expression pa transcriptional milingo pamaso pa tunicamycin.Melatonin imalepheretsa mawu a COX-2 opangidwa ndi tunicamycin m'maselo a MDA-MB-231.Kuphatikiza apo, kuletsa kwa COX-2 ntchito pogwiritsa ntchito COX-2 inhibitor, NS398, kumawonjezera apoptosis ya tunicamycin.Chochititsa chidwi, izi sizinagwirizane ndi njira za melatonin receptor.Pertussis toxin (general Gi protein inhibitor) kapena luzindole (wosagwirizana ndi melatonin receptor antagonist) sanasinthe zotsatira za melatonin.Kuphatikiza apo, melatonin inaletsa ntchito ya NF-κB yolembedwa ndi tunicamycin, translocation ya nyukiliya ya p65, ndi p38 MAPK act ivation.Kuletsa kwa Melatonin-mediated p38 MAPK kunathandizira kuchepetsa kukhazikika kwa COX-2 mRNA.Kutengera pamodzi, zotsatira zathu zikuwonetsa kuti melatonin imathandizira ntchito ya antitumor kudzera pakuwongolera kwa Bim expression ndi kutsitsa-mawu a COX-2 m'maselo a MDA-MB-231 opangidwa ndi tunicamycin.
