Zogulitsa

Mafilimu a mucoadhesive okhala ndi curcumin-loaded nanoparticles adapangidwa, cholinga chotalikitsa nthawi yokhala ndi mawonekedwe a mlingo m'kamwa ndi kuonjezera kuyamwa kwa mankhwala kudzera mu buccal mucosa.Mafilimu adakonzedwa ndi njira yoponyera pambuyo pophatikizira ma curcumin-wodzaza chitosan-wokutidwa ndi polycaprolactone nanoparticles muzitsulo za chitosan zapulasitiki.Mitundu yosiyanasiyana ya molar ya mucoadhesive polysaccharide chitosan ndi kuchuluka kwa plasticizer glycerol idagwiritsidwa ntchito kukhathamiritsa zokonzekera.Makanema omwe adapezeka pogwiritsa ntchito chitosan chapakati komanso chapamwamba kwambiri adapezeka kuti ndi ofanana komanso osinthika.Ma nanoparticles odzaza ndi curcumin adagawidwa mofanana pamtunda wa filimuyo, monga umboni wa microscope ya atomiki ndi zithunzi zamfuti zamtundu wa electron microscopy (FEG-SEM).Kuwunika kwa magawo amtundu wa kanema pogwiritsa ntchito FEG-SEM kukuwonetsa kukhalapo kwa nanoparticles mkati mwa makanema.Kuonjezera apo, mafilimu adawonetsa kuti ali ndi mlingo wabwino wa hydration mu njira yowonongeka ya malovu, kusonyeza kutupa kwakukulu kwa pafupifupi 80% ndi mu vitro kutulutsa curcumin motalika.Zotsatirazi zikuwonetsa kuti mafilimu a mucoadhesive omwe ali ndi nanoparticles amapereka njira yodalirika yoperekera buccal ya curcumin, yomwe ingakhale yothandiza kwambiri pochiza matenda a periodontal omwe amafunikira kupereka mankhwala osatha.© 2014 Wiley Periodicals, Inc. ndi American Pharmacists Association.