Zogulitsa

Pamaziko a ATP adenine, mndandanda wa adenine ndi purine zotumphukira zinakonzedwa ndikuyesedwa kuti athe kuletsa kuchuluka kwa kinase okhudzana ndi matenda.Pakhala pali kafukufuku wochepa wofufuza kuthekera kwa cosubstrate derived kinase inhibitors kwa kinase ena kuposa ma CDK.Mapangidwe athu a inhibitor anaphatikiza dongosolo la purine kuchokera ku cosubstrate yapachiyambi ya ATP ndi phenyl moieties kuti afufuze zotheka kuyanjana ndi madera osiyanasiyana a malo omangiriza a ATP mu mapuloteni ambiri okhudzana ndi matenda.Pakhala pali kumenyedwa kwa zinthu zomwe zayesedwa, zomwe zidatipangitsa kuganiza kuti kuchulukana kwamagulu kumatha kukhala chida chamtengo wapatali pakuwunika kwa kulumikizana ndi kusankha kwamitundu yosiyanasiyana ya kinase.