Zogulitsa

Streptavidin ndi ma homologs ake (pamodzi otchedwa streptavidin) amagwiritsidwa ntchito kwambiri mu sayansi ya maselo chifukwa cha kugwirizana kwawo kokhazikika komanso kokhazikika ndi biotin.Zinthu zina zimathandizanso kutchuka kwa dongosolo la streptavidin-biotin, kuphatikizapo kukhazikika kwa mapuloteni ndi njira zosiyanasiyana za mankhwala ndi enzymatic biotinylation zomwe zilipo kuti zigwiritsidwe ntchito ndi mapangidwe osiyanasiyana oyesera.Ukadaulowu wasangalala ndi kubwezeretsedwa kwamtundu wina m'zaka zaposachedwa, popeza mitundu yatsopano ya streptavidin imapangidwa kuti igwirizane ndi mapuloteni akubadwa ndipo njira zatsopano zodziwitsira biotinylation zosankhidwa zimapangidwira mu vitro komanso mu vivo application.Pakhala zochitika zodziwikiratu m'magawo a catalysis, cell biology, ndi proteinomics kuwonjezera pakugwiritsa ntchito mosalekeza m'malo odziwika bwino ozindikira, kulemba zilembo ndi kutumiza mankhwala.Ndemangayi ikufotokoza mwachidule zapita patsogolo kwaposachedwa kwa streptavidin engineering ndi ntchito zatsopano zochokera ku streptavidin-biotin interaction.