Uridine, 2'-deoxy-5-ethynyl- Cas: 61135-33-9
| Nambala ya Catalog | XD90589 |
| Dzina lazogulitsa | Uridine, 2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Molecular Formula | C11H12N2O5 |
| Kulemera kwa Maselo | 252.23 |
| Zambiri Zosungira | -20 ° C |
| Harmonize Tariff Code | 29349990 |
Mafotokozedwe a Zamalonda
| Maonekedwe | White mpaka Orange mpaka Green ufa mpaka kristalo |
| Kuyesa | ≥99% |
Kafukufukuyu adachitidwa kuti afufuze kuchuluka kwa ma peptide a soya amasamba pama cell tsinde akulu (ASCs) pakalibe seramu ndi njira zawo zogwirira ntchito.Kuchulukitsa kwa maselo amtundu wa mesenchymal stem cell (ADSCs) ndi ma cell a mesenchymal stem cell (CB-MSCs) omwe amapangidwa ndi soya peptides adapezeka kuti akuwonjezeka kwambiri pa 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide ndi Dinani-iT 5-ethynyl-2'-deoxyuridine flow cytometry assay.Kuphatikiza apo, ma soya peptides adatsogolera ku phosphorylation ya p44/42 MAPK (ERK), chandamale cha mammalian cha rapamycin (mTOR), p70 S6 kinase, S6 ribosomal protein (S6RP) ndi eukaryotic initiation factor 4E (eIF4E) mu ADSCs.Kuphatikiza apo, kuwunika kochulukira kwa ma cytokines kunawonetsa kuti kupanga kusintha kwa kukula kwa beta1 (TGF-β1), vascular endothelial growth factor ndi interleukin-6 idakula kwambiri poyankha chithandizo ndi soya peptides mu ADSCs ndi CB-MSCs.Mofananamo, phosphorylation ya soy peptide-induced phosphorylation ya njira ya ERK/mTOR/S6RP/eIF4E idatsekedwa poyankha pretreatment ndi PD98059, ERK inhibitor yeniyeni.Komanso, kuletsa kwa TGF-β1 kupyolera mu PD98059 pretreatment ndi kuchepa motsatizana ndi kuwonjezeka kwa ADSC kunawonetsa kuti TGF-β1 imapangitsa phosphorylation ya mTOR/S6RP/eIF4E.Zonsezi, zotsatira za kafukufukuyu zikuwonetsa kuti kupanga kwa TGF-β1 modalira ERK kumagwira ntchito yofunika kwambiri pakuchulukirachulukira kwa soya peptide ya ADSC pansi pamikhalidwe yopanda seramu.Copyright © 2012 Elsevier Inc. Ufulu wonse ndi wosungidwa.
