Zogulitsa

Citicoline (CDP-choline) ndi mkhalapakati wofunikira mu biosynthesis ya phosphatidylcholine, chigawo chofunikira cha neural cell membrane.Zasonyezedwa kuti zimabweretsa zopindulitsa pazitsanzo za nyama ndi mayesero omwe si a US clinic stroke.Kafukufukuyu anali ndi mayesero osasinthika (3 Mlingo wa citicoline ku 1 placebo), mayesero oyendetsedwa ndi galimoto, akhungu awiri pa 21 US centers.Chithandizo chinayenera kuyambika mkati mwa maola 24 kuchokera ku sitiroko ndipo chinapitilizidwa pakamwa kwa masabata 6.Zotsatira zomaliza zowunika zinali pa masabata a 12.Odwala mazana awiri ndi makumi asanu ndi anayi adalembedwa, ndipo pafupifupi 65 m'magulu anayi onsewa.Nthawi yochuluka kuchokera ku sitiroko ikuyamba kulandira chithandizo inali maola 14.5, ndipo panalibe kusiyana kwakukulu kwa makhalidwe oyambirira pakati pa magulu anayi kupatulapo kulemera kwa odwala.Kusiyana kwakukulu pakati pa magulu, kukonda chithandizo cha citicoline, kunawoneka potengera zotsatira za ntchito monga momwe Barthel Index ndi Rankin sikelo, kuwunika kwa neurologic monga momwe kuyesedwa ndi National Institutes of Health (NIH) stroke scale, ndi chidziwitso cha chidziwitso monga momwe amachitira The Mini Mental Status Examination.Pamene chiwerengero choyambirira cha NIH stroke scale chinagwiritsidwa ntchito ngati covariate, gulu la citicoline la 500-mg ndi gulu la citicoline la 2,000-mg linali ndi kusintha kwakukulu pa chiwerengero cha odwala omwe anali ndi zotsatira zabwino pa Barthel Index pa masiku a 90.Panalibe zochitika zazikulu zokhudzana ndi mankhwala kapena imfa mu kafukufukuyu.Kafukufukuyu akuwonetsa kuti oral citicoline angagwiritsidwe ntchito mosatekeseka ndi zotsatira zochepa pa chithandizo cha stroke.Citicoline ikuwoneka kuti ikuwongolera zotsatira zogwira ntchito ndikuchepetsa kuchepa kwa neurologic ndi 500 mg ya citicoline ikuwoneka ngati mlingo woyenera.