Zogulitsa

Nickel ndi mankhwala omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda: Helicobacter pylori.Zoonadi, H. pylori ali ndi ma nickel-enzymes awiri omwe ali ofunikira mu vivo colonization, [NiFe] hydrogenase ndi urease, chinthu chochuluka cha virulence chomwe chili ndi 24 nickel ions pa zovuta zogwira ntchito.Chifukwa cha ma enzyme awiriwa, kupulumuka kwa H. pylori kumadalira pamtengo wofunikira wa nickel, kutanthauza kulamulira molimba kwa kugawa ndi kusungidwa kwake.Mu ndemangayi, tidzapereka njira zogwiritsira ntchito ma enzymes a nickel komanso njira zoyambilira zomwe zimapezeka mu H. pylori kuti atenge, kugulitsa ndi kugawa nickel pakati pa ma enzyme awiri.Izi zikuphatikiza (i) makina otengera faifi wakunja kwa membrane, chonyamula chodalira FrpB4 TonB, (ii) ma protein complexes ophatikizika ndi maukonde olumikizana omwe akukhudzidwa ndi malonda a faifi tambala ndi kugawa pakati pa urease ndi hydrogenase ndi, (iii) Helicobacter yeniyeni yomanga nickel mapuloteni zomwe zimakhudzidwa ndi kusungirako nickel ndipo zimatha kukhala ngati metallo-chaperones.Pomaliza, tikambirana tanthauzo la anthu ozembetsa nickel mu virulence ndikuwapanga ngati njira zatsopano zochizira matenda a H. pylori.