Zogulitsa

Njira imodzi yofunika kwambiri yochizira matenda amtundu wa 2 ndi kugwiritsa ntchito mankhwala omwe amatha kuchepetsa postprandial hyperglycemia poletsa ma enzyme omwe amagayidwa ndi chakudya.Kafukufuku wapano adafufuza za zotsatira za bioassay-guided extract ndi tizigawo ta zipatso zouma pericarp ya Phaleria macrocarpa, chomera choletsa matenda a shuga, pa α-glucosidase ndi α-amylase, pofuna kumvetsetsa njira yawo yolimbana ndi matenda a shuga, monga Kuchulukitsa kwa shuga wa postprandial (ME), yomwe imapezeka pochotsa zosungunulira motsatizana, kagawo kake kamadzimadzi kamadzimadzi kamadzimadzi a n-butanol (NBF) ndi gawo laling'ono la chromatographic (SFI), adawunikidwa. kwa in vitro α-glucosidase (yeast) ndi α-amylase (nkhumba) zoletsa ntchito.Kuphatikiza apo, kutsimikizira mu vivo kuyezetsa kunachitika mu makoswe a streptozotocin-induced diabetic (SDRs) pogwiritsa ntchito mayeso a shuga wapakamwa, sucrose ndi wowuma. 75%) ndi α-amylase (87%) mu vitro (IC50 = 2.40 ± 0.23 μg/ml ndi 58.50 ± 0.13 μg/ml, motsatira) motsatira mlingo;zotsatira zopezeka pafupifupi 20% kuposa acarbose (55%), muyezo wa α-glucosidase inhibitor (IC50 = 3.45 ± 0.19 μg/ml).ME ndi SFI zinaletsanso α-glucosidase (IC50 = 7.50 ± 0.15 μg/ml ndi 11.45 ± 0.28 μg/ml) ndi α-amylase (IC50 = 43.90 ± 0.19 μg/ml. pang'ono.M'maphunziro a vivo okhala ndi makoswe a matenda a shuga, NBF ndi SFI zidachepetsa kuchuluka kwa shuga m'magazi (PBG) ndi 15.08% ndi 6.46%, ndi dera lomwe lili pansi pa curve tolerance (AUC) ndi 14.23% ndi 12.46%, motsatana, pambuyo pa vuto la sucrose pakamwa. (P <0.05);potero kutsimikizira zomwe zawonedwa mu vitro.Zotsatira zochepetsera izi pa PBG ndi AUC zidawonetsedwanso pakuyesa kulolera kwa shuga ndi wowuma, koma pang'ono. Zotsatirazi zikuwonetsa kuti P. macrocarpa imatha kutsitsa hyperglycemia mu in vitro komanso mu vivo poletsa mwamphamvu ma carbohydrate hydrolysing enzymes, kupangitsa chomera chothandiza kupeza zinthu zachilengedwe zowongolera matenda amtundu wa 2 mellitus.