Zogulitsa

Kufufuza zotsatira za mafuta a spearmint pa kusintha kwa emphysema-monga ndi mawu a chotupa necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) ndi minofu yoletsa metalloproteinase -1 (TIMP-9) mu lipopolysaccharide (LPS) mankhwala makoswe.Emphysematous kusintha chitsanzo anakopeka ndi intracheal instillation wa LPS kamodzi pa sabata kwa masabata 8 mu makoswe.Makoswe adagawidwa kukhala olamulira, dexamethasone (0.3 mg x kg (-1)), ndi mafuta a spearmint (10, 30,100 mg x kg (-1)) magulu.Gulu lirilonse lidathandizidwa ndi saline, dexamethasone, ndi spearmint wamafuta motsatana kwa milungu inayi.Kenako kuchuluka kwa maselo oyera amwazi mu bronchoalveolar lavage fluid (BALF) kunachitika.Kusintha kwamphamvu kwa minofu ya m'mapapo monga mawonekedwe a alveolar, kutupa kwa mpweya, ndi goblet cell metaplasia adawonedwa ndi madontho a HE ndi AB-PAS.Mafotokozedwe a TNF-alpha, IL-1beta, TIMP-1 ndi MMP-9 anayesedwa. Onse spearmint ndi dexamethasone anachepetsa chiwonongeko cha pulmonary alveolus.Maselo oyera a magazi onse ndi osiyana mu BALF kuphatikizapo neutrophile ndi lymphocyte ya mafuta a spearmint 100 mg x kg (-1) ndi gulu la dexamethasone linachepetsedwa kwambiri, ndipo goblet cell metaplasia inaletsedwanso.Dexamethasone inali ndi mphamvu yolepheretsa mawu a TNF-alpha, IL-1beta, TIMP-1 ndi MMP-9.Mafuta a Spearmint 30, 100 mg x kg (-1) amachepetsa kwambiri TNF-alpha ndi IL-1beta motsatira.Mafuta a Spearmint 10, 30 ndi 100 mg x kg (-1) analibe mphamvu pa mawu a TIMP-1, koma amatha kuchepetsa mawu a MMP-9 kwambiri m'mapapo a m'mapapo. chifukwa amathandizira kuwonongeka kwa alveolar, kutupa kwa pulmonary, ndi goblet cell metaplasia.Makinawa angaphatikizepo kuchepetsa zomwe zili mu TNF-alpha, IL-1beta ndikuletsa kuchulukitsidwa kwa matrix metalloproteinase-9 m'mapapo.