Zogulitsa

BBS4 ndi imodzi mwamapuloteni angapo omwe kupunduka kwawo kumayambitsa matenda a Bardet-Biedl (BBS), matenda amitundumitundu, omwe amawonetsa kunenepa kwambiri.Ma polymorphisms a BBS4 adalumikizidwa ndi kunenepa wamba komwe sikungakhale kwa Syndromic morbid.BBS4 kunenepa kwambiri kwa ma molekyulu, ndi gawo la jini ya BBS4 pakusiyanitsa ndi ntchito za adipocyte sizidziwika bwino.Tsopano tikuwonetsa kuti Bbs4 imagwira gawo lachindunji komanso lofunikira pakuchulukira ndi adipogenesis: kutonthola kwa Bbs4 mu 3T3F442A preadipocytes kumapangitsa kuti ma cell agawidwe mwachangu komanso kusiyanitsa kosiyana, kuwonekera kudzera mu maphunziro a morphologic (kuwala, kusanthula ndi kufalitsa ma electron microscopy), kusanthula kwamafuta, kusanthula kwamafuta, mafuta acid profile ndi lipolysis) ndi zolembera za adipogenic (Cebpα, Pparγ, aP2, ADRP, Perilipin).Munthawi yonse ya adipogenesis komanso akatsutsidwa ndi kuchuluka kwamafuta, ma cell a Bbs4 amatonthola amaunjikana kwambiri triglycerides kuposa kuwongolera adipocytes, ngakhale m'malo ang'onoang'ono (komanso ochulukirapo) omwe ali ndi mbiri yamafuta acid osinthidwa.Chifukwa chake, kuchuluka kwamafuta ambiri m'maselo osalankhula ndi chotsatira cha kuchuluka kwa kuchuluka kwa adipocyte komanso kusiyanasiyana kwapang'onopang'ono komwe kumapangitsa kuti mafuta azichulukirachulukira pa cell.Zomwe tapeza zikuwonetsa kuti kunenepa kwambiri kwa BBS kungakhale chifukwa cha gawo lachindunji la BBS4 mumayendedwe amthupi ndi a pathophysiological omwe amathandizira kupanga minofu ya adipose yokhudzana ndi kunenepa kwambiri.