Zogulitsa

RasGrf1 ndi RasGrf2 ndi zinthu zomwe zimasinthiratu ma guanine nucleotide zomwe zimatha kuyambitsa ma Ras kapena Rho GTPases.Ma jini a RasGrf amafotokozedwa bwino mkatikati mwa minyewa, ngakhale kuti mawu enaake amtundu uliwonse amathanso kuchitika kwina.RasGrf1 ndi jini yofotokozedwa ndi abambo yomwe imawonetsedwa pambuyo pobadwa.Mosiyana ndi izi, RasGrf2 sinasindikizidwe ndipo ikuwonetsa mawonekedwe okulirapo.Mitundu yosiyanasiyana ya ma jini onsewa imapezekanso pama cell osiyanasiyana.Mapuloteni a RasGrf amawonetsa ma modular opangidwa ndi madera angapo kuphatikiza CDC25H ndi DHPH motifs omwe ali ndi udindo wolimbikitsa kusinthana kwa GDP/GTP, motsatana, pazolinga za Ras kapena Rho GTPase.Madera osiyanasiyana ndi ofunikira kuti afotokoze zomwe akuchita komanso kusintha momwe amagwirira ntchito kuti athe kulumikiza ma siginecha osiyanasiyana akumtunda ku milingo yosiyanasiyana yakumunsi ndi mayankho amafoni.Ngakhale kuti ali ndi ma homology, RasGrf1 ndi RasGrf2 amawonetsa zosiyana siyana zomwe akufuna komanso ntchito zomwe sizimayenderana m'malo osiyanasiyana osayina okhudzana ndi kukula kwa ma cell ndi kusiyanitsa komanso kusangalatsa kwa neuronal ndi kuyankha kapena synaptic plasticity.Ngakhale kuti ma RasGrfs onse amatha kugwiritsidwa ntchito ndi ma glutamate receptors, G-protein-coupled receptors kapena kusintha kwa intracellular calcium concentration, RasGrf1 yokha imanenedwa kuti imayendetsedwa ndi LPA, cAMP, kapena agonist-activated Trk ndi cannabinoid receptors.Kuwunika kwa mitundu yosiyanasiyana ya mbewa zogogoda kwavumbulutsa momwe RasGrf1 imagwirira ntchito pakukumbukira ndi kuphunzira, kujambula zithunzi, kuwongolera kukula kwapambuyo pobereka komanso kukula kwa thupi ndi ntchito ya pancreatic β-cell ndi glucose homeostasis.Kwa RasGrf2, maudindo apadera pakuchulukira kwa ma lymphocyte, mayankho owonetsa ma T-cell ndi lymphomagenesis afotokozedwa.