Zogulitsa

Ma guanosine analogues angapo, mwachitsanzo, acyclovir (ndi oral prodrug valaciclovir), penciclovir (mu mawonekedwe ake oral prodrug, famciclovir) ndi ganciclovir, amagwiritsidwa ntchito kwambiri pochiza herpesvirus [ie herpes simplex virus type 1 (HSV-1), ndi mtundu 2 (HSV-2), varicella-zoster virus (VZV) ndi/kapena human cytomegalovirus (HCMV)].M'zaka zaposachedwa, ma analogue angapo atsopano a guanosine apangidwa, kuphatikiza 3-membered cyclopropylmethyl ndi -methenyl zotumphukira (A-5021 ndi synguanol) ndi 6-memberly D- ndi L-cyclohexenyl zotumphukira.Ntchito ya acyclic/carbocyclic guanosine analogues yatsimikiziridwa motsutsana ndi ma virus osiyanasiyana, kuphatikiza HSV-1, HSV-2, VZV, HCMV, komanso mtundu wa 6 wa herpesvirus (HHV-6), mtundu 7 (HHV- 7) ndi mtundu 8 (HHV-8), ndi kachilombo ka hepatitis B (HBV).Ma guanosine analogues atsopano (ie A-5021 ndi D- ndi L-cyclohexenyl G) adapezeka kuti akugwira ntchito kwambiri polimbana ndi ma virus (HSV-1, HSV-2, VZV) omwe amasunga thymidine kinase (TK), kutanthauza. kuti ntchito yawo yoletsa mavairasi (osachepera pang'ono) imadalira phosphorylation ndi TK yoyambitsidwa ndi kachilomboka.Zolemba zoletsa antiviral zidadziwikanso ndi A-5021 motsutsana ndi HHV-6 komanso ndi D- ndi L-cyclohexenyl G motsutsana ndi HCMV ndi HBV.Ntchito yoletsa ma virus ya ma acyclic/carbocyclic nucleoside analogues imatha kulimbikitsidwa kwambiri ndi mycophenolic acid, inhibitor yamphamvu ya inosine 5'-monophosphate (IMP) dehydrogenase.The carbocyclic guanosine analogues (ie A-5021 ndi D- ndi L-cyclohexenyl G) ali ndi lonjezo lalikulu, osati ngati antiviral wothandizira pochiza matenda a herpesvirus, komanso antitumor wothandizira ophatikizana jini mankhwala/chemotherapy ya khansa, malinga ngati (gawo la) maselo otupa asinthidwa ndi jini ya TK ya virus (HSV-1, VZV).