Zogulitsa

Cerebral dopamine neurotrophic factor (CDNF) protein yawonetsedwa kuti imateteza njira ya nigrostriatal dopaminergic ikaperekedwa ngati intrastriatal infusions mumitundu ya makoswe ndi mbewa ya matenda a Parkinson (PD).Mu phunziro ili, tidawunika mphamvu ya neuroprotective ya CDNF yoperekedwa ndi recombinant adeno-associated viral (AAV) serotype 2 vector mu rat 6-hydroxydopamine (6-OHDA) chitsanzo cha PD.Ma Vector a AAV2 otsekera CDNF, glial cell line-derived neurotrophic factor (GDNF), kapena mapuloteni obiriwira a fulorosenti adabayidwa mu rat striatum.Kusanthula kawonekedwe ka mapuloteni kunawonetsa kuti vekitala yathu ya AAV2 idapereka bwino majini a neurotrophic factor muubongo ndikupangitsa kuti mapuloteni azikhala kwanthawi yayitali.Patatha milungu iwiri jakisoni wa vekitala ya AAV2, 6-OHDA idabayidwa mu rat striatum, ndikupangitsa kuchepa kwapang'onopang'ono kwa dongosolo la nigrostriatal dopaminergic.Chithandizo cha AAV2-CDNF chinapangitsa kuchepa kwakukulu kwa kasinthasintha kwa amphetamine-ipsilateral pomwe amateteza pang'ono chabe maselo a tyrosine hydroxylase (TH) -immunoreactive mu rat substantia nigra pars compacta ndi TH-reactive fibers mu striatum.Zotsatira za phunziroli zimapereka umboni wina wosonyeza kuti CDNF ikhoza kuonedwa ngati chithandizo chamankhwala a Parkinson.