Doxifluridine Cas: 3094-09-5
| Nambala ya Catalog | XD90592 |
| Dzina lazogulitsa | Doxifluridine |
| CAS | 3094-09-5 |
| Molecular Formula | Chithunzi cha C9H11FN2O5 |
| Kulemera kwa Maselo | 246.20 |
| Zambiri Zosungira | 2 mpaka 8 ° C |
| Harmonize Tariff Code | 29349990 |
Mafotokozedwe a Zamalonda
| Maonekedwe | White mpaka woyera crystalline ufa |
| Kuyesa | ≥99% |
| Melting Point | 189 - 193 ° C |
Fluorouracil antineoplastic mankhwala ndi mankhwala a fluorouracil.The thymidine phosphorylase alipo mu chotupa minofu amachita pa izo kuti atembenuke mu fluorochemicalbook uracil mu chotupa, potero kusonyeza odana ndi chotupa kwenikweni.Makhalidwe ake odana ndi chotupa ndi amphamvu, ndipo kawopsedwe kake ndi kochepa.Kuchipatala ntchito khansa chapamimba, khansa ya m'mimba, khansa ya m'mawere, mlingo chikhululukiro akhoza kufika oposa 30%.
Mphamvu ya systemic chemotherapy pakufalitsa khansa ya m'mimba sikudziwika bwino.Kuchita bwino kwa paclitaxel mlungu uliwonse kuphatikiza doxifluridine (5'-DFUR) mwa odwala khansa ya m'mimba ndi ma ascites owopsa adawunikidwa.Mankhwalawa anali a paclitaxel kudzera m'mitsempha (iv) yoperekedwa pa 80 mg/m(2) masiku 1, 8 ndi 15 milungu inayi iliyonse, ndipo doxifluridine imaperekedwa pakamwa pa 533 mg/m(2) masiku 1-5 sabata iliyonse.Kuyankha kwa odwala omwe ali ndi ascites kunatsimikiziridwa kutengera Gulu la Japan la Gastric Carcinoma.Komanso, kuchuluka kwa paclitaxel mu ascites kunayesedwa.Odwala makumi awiri ndi anayi adafufuzidwa.Mlingo woyankha (RR) unali 41.7%, kuphatikiza kukhululukidwa kwathunthu (CR) ndi kukhululukidwa pang'ono (PR) mwa odwala 4 ndi 6, motsatana.Kuchuluka kwa paclitaxel mu ascites kunasungidwa pakati pa 0.01 μM ndi 0.05 μM mpaka maola 72.Kupulumuka kwapakatikati (OS) kunali masiku 215, ndipo kupulumuka kwa chaka chimodzi kunali 29.2%.No kwambiri kawopsedwe anali anazindikira.Weekly paclitaxel osakaniza doxifluridine ndi ogwira khansa chapamimba odwala ndi zilonda ascites ndi chovomerezeka kawopsedwe mbiri.
