Zogulitsa

Umboni waposachedwa umathandizira kuti β-nicotinamide adenine dinucleotide (β-NAD(+)) ikhale yodziwika bwino ya neurotransmitter ndi neuromodulator mu dongosolo lamanjenje -β-NAD(+) imatulutsidwa mumitsempha-yosalala yokonzekera minofu ndi ma cell a adrenal chromaffin. m'njira yodziwika bwino ya neurotransmitter.Sizikudziwika ngati izi ndi zoona kwa CNS.Pogwiritsa ntchito kayezedwe kachipinda kakang'ono ka superfusion ndi njira zodziwikiratu zamphamvu kwambiri zamadzimadzi, tikuwonetsa kuti kukondoweza kwa K(+) kwa makoswe a forebrain synaptosomes kumabweretsa kusefukira kwa β-NAD(+) , adenosine 5'-triphosphate, ndi metabolites adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate, adenosine, ADP-ribose (ADPR) ndi cyclic ADPR.Kusefukira kwapamwamba-K(+) -kusefukira kwa β-NAD(+) kumachepetsedwa ndi kung'ambika kwa SNAP-25 ndi botulinum neurotoxin A, poletsa njira za N-mtundu wodalira magetsi a Ca (2+) okhala ndi ω-conotoxin GVIA. , ndi kuletsa kwa proton gradient ya synaptic vesicles yokhala ndi bafilo mycin A1, kutanthauza kuti β-NAD(+) imatulutsidwa kudzera mu vesicle exocytosis.Kusanthula kwa kumadzulo kumasonyeza kuti CD38, mapuloteni ochuluka omwe amagwiritsira ntchito β-NAD (+) , amapezeka pa synaptosomal membranes ndi cytosol.Ma synaptosomes osakhazikika amawononga β-NAD(+) .1,N (6) -etheno-NAD, analogue ya fulorosenti ya β-NAD (+) , imatengedwa ndi ma synaptosomes ndipo kutengeka kumeneku kumachepetsedwa ndi β-NAD (+) yeniyeni, koma osati ndi connexin 43 inhibitor Gap 27. Mu ma cortical neurons kugwiritsa ntchito kwa β-NAD(+) kumapangitsa kuti Ca(2+) ikhale yofulumira, mwina chifukwa cha kuchuluka kwa Ca(2+) .Chifukwa chake, ma synaptosomes a ubongo wa makoswe amatha kumasula mwachangu, kunyozetsa ndi kutenga β-NAD(+) , ndipo β-NAD(+) imatha kulimbikitsa ma postsynaptic neurons, njira zonse zofunika kuti chinthucho chiwoneke ngati chothandizira muubongo.