Zogulitsa

Kupanga kwa Acyl-CoA kumayambitsa metabolism yamafuta acid.Acyl-CoAs amapangidwa ndi kuphatikizika kwa mafuta acid kupita ku Coenzyme A yolumikizidwa ndi banja lalikulu la acyl-CoA synthetases (ACS).Mosiyana ndi zimenezi, acyl-CoAs akhoza hydrolyzed ndi banja la acyl-CoA thioesterases (ACOT).Apa, tatsimikiza malamulo olembedwa a ma enzymes onse a ACS ndi ACOT kudutsa minofu komanso poyankha kusokonezeka kwa metabolic.Timapeza machitidwe ogwirizana mkati ndi pakati pa mabanja a majiniwa komanso malamulo apadera omwe amachitika m'njira yodalira minofu ndi thupi.Chifukwa chowona kusintha kwa unyolo wautali wa ACOT mRNA ndi kuchuluka kwa mapuloteni m'chiwindi ndi minofu ya adipose, tidazindikira zotsatira za kuchuluka kwa ntchito ya cytosolic yautali-chain thioesterase pamafuta acid metabolism m'matumbowa popanga mbewa za transgenic zomwe zimawonetsa kusintha kwakukulu kwa Acot7 mu chiwindi kapena minofu ya adipose.Kuwirikiza kawiri ntchito ya cytosolic acyl-CoA thioesterase inalephera kuteteza mic e ku kunenepa kwambiri chifukwa cha zakudya, chiwindi chamafuta kapena insulin kukana, komabe, kuchulukitsidwa kwa Acot7 mu adipocytes kumapangitsa mbewa kusalolera kuzizira.Pamodzi, deta iyi imasonyeza njira zosiyana zoyendetsera ma ACS ndi ma enzymes a ACOT komanso kuti ma enzymeswa amagwira ntchito molumikizana kuti athe kuwongolera kagayidwe ka mafuta m'thupi motengera minofu.