Spiramycin Cas: 8025-81-8
| Nambala ya Catalog | XD90452 |
| Dzina lazogulitsa | Spiramycin |
| CAS | 8025-81-8 |
| Molecular Formula | Chithunzi cha C43H74N2O14 |
| Kulemera kwa Maselo | 843.05 |
| Zambiri Zosungira | 2 mpaka 8 ° C |
| Harmonize Tariff Code | 29419000 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Ufa Woyera |
| Kuyesa | > 4100 IU/mg |
| Zitsulo zolemera | <20ppm |
| Kutaya pa Kuyanika | <3.5% |
| Phulusa la Sulfate | <1.0% |
| Ethanol | <2.0% |
| Kuzungulira kwapadera kwa kuwala | -85 mpaka -80 madigiri |
Streptomyces ambofaciens amapanga macrolide antibiotic spiramycin.Gulu la jini la biosynthetic la spiramycin ladziwika ndi S. ambofaciens.Kuphatikiza pa jini yoyang'anira srmR (srm22), yomwe idadziwika kale (M. Geistlich et al., Mol. Microbiol. 6: 2019-2029, 1992), majini atatu owongolera adadziwika ndikuwunika motsatizana.Kusanthula kwa ma gene ndi kuyesa koyambitsa jini kunawonetsa kuti imodzi yokha mwa jini itatuyi, srm40, imagwira ntchito yayikulu pakuwongolera spiramycin biosynthesis.Kusokonezeka kwa srm22 kapena srm40 kunathetsa kupanga spiramycin pomwe kufotokoza kwawo mopambanitsa kumawonjezera kupanga spiramycin.Kusanthula kwamafotokozedwe kunachitika ndi reverse transcription-PCR (RT-PCR) pamitundu yonse yamagulu amtundu wamtchire komanso mu srm22 (srmR) ndi srm40 deletion mutants.Zotsatira za kusanthula kwa mawuwo, limodzi ndi zomwe zayeserera kowonjezera, zidawonetsa kuti Srm22 ndiyofunikira pa mawu a srm40, Srm40 kukhala choyambitsa chapadera chomwe chimawongolera kwambiri, ngati si onse, amtundu wa spiramycin biosynthetic.
