Zogulitsa

Sitagliptin ndi mankhwala omwe ali m'gulu la mankhwala otchedwa dipeptidyl peptidase-4 (DPP-4) inhibitors.Amagwiritsidwa ntchito makamaka pakuwongolera matenda amtundu wa 2 mellitus.Matenda a shuga amachitika pamene thupi limalephera kuwongolera kuchuluka kwa shuga m'magazi, zomwe zimapangitsa kuchuluka kwa shuga m'magazi.Mahomoniwa amathandizira katulutsidwe ka insulini ndikuchepetsa kupanga glucagon, zomwe zimapangitsa kuti shuga asamayende bwino.Poletsa enzyme ya DPP-4, sitagliptin imalola kuti ma incretin azitha kugwira ntchito kwa nthawi yayitali, motero amawongolera kuwongolera shuga m'magazi.Mlingo woperekedwa ndi dokotala umatengera zomwe wodwala ali nazo, monga kuopsa kwa matenda a shuga ndi mankhwala ena omwe akugwiritsidwa ntchito.Ndikofunikira kutsatira malangizo operekedwa mosamala komanso osasintha mlingo popanda kukaonana ndi dokotala.Sitagliptin nthawi zambiri amagwiritsidwa ntchito ngati chothandizira pazakudya komanso kuchita masewera olimbitsa thupi pakuwongolera matenda a shuga a 2.Nthawi zambiri amaperekedwa limodzi ndi kusintha kwa moyo komanso mankhwala ena ochepetsa shuga, monga metformin.Mwa kuphatikiza njira zosiyanasiyana zochitira zinthu, monga sitagliptin's DPP-4 inhibition ndi metformin yopititsa patsogolo chidwi cha insulin, kuwongolera bwino kwa glycemic kumatha kutheka.Kafukufuku wasonyeza kuti imatha kutsitsa shuga wosala kudya komanso wapambuyo (pambuyo pa chakudya), kuchepetsa kuchuluka kwa hemoglobin ya glycated (HbA1c), komanso kuwongolera glycemic control. monga mutu, matenda am'mwamba a kupuma, ndi kusokonezeka kwa m'mimba monga nseru kapena kutsekula m'mimba.Monga momwe zimakhalira ndi mankhwala aliwonse, kuyabwa kwambiri komanso zovuta zina zomwe zimachitika kawirikawiri koma zovuta kwambiri zimatha kuchitika, motero ndikofunikira kuti mudziwitse dokotala nthawi yomweyo zizindikiro zilizonse zachilendo kapena zovuta. Mwachidule, sitagliptin ndi mankhwala omwe amagwiritsidwa ntchito pochiza matenda a shuga a 2. .Monga inhibitor ya DPP-4, imathandizira kuwongolera glycemic ndikutalikitsa ntchito ya ma incretin.Ikagwiritsidwa ntchito limodzi ndi kusintha kwa moyo ndi mankhwala ena ochepetsa shuga, sitagliptin imatha kukhala chida chothandiza pakuwongolera kuchuluka kwa shuga m'magazi ndikuwongolera matenda amtundu wa 2.Kuyang'anitsitsa ndi kukaonana ndi dokotala ndikofunikira kuti pakhale zotsatira zabwino.