Zogulitsa

Rosuvastatin Intermediates ZD9, yomwe imadziwikanso kuti Z-4-(4-Fluorophenyl)-6-Isopropyl-2--[(N-Methyl-N-Methylsulfonyl)Amino]Pyrimidin-5-Yl, ndi mankhwala omwe amagwira ntchito yofunika kwambiri. wapakatikati pakuphatikizika kwa mankhwala ochepetsa cholesterol a Rosuvastatin.Izi zapakatikati zimagwira ntchito yofunika kwambiri popanga Rosuvastatin, yomwe ili m'gulu la mankhwala otchedwa statins.ZD9 amagwira ntchito ngati kalambulabwalo pakupanga kwa Rosuvastatin.Pakupanga, ZD9 imasinthidwa mosiyanasiyana kuti itulutse chomaliza, Rosuvastatin.Kaphatikizidwe kameneka kakuphatikiza kuphatikizika kwa magulu owonjezera ogwira ntchito pa molekyulu ya ZD9, zomwe zimapangitsa kuti pakhale mankhwala omwe amathandizira, Rosuvastatin.Rosuvastatin amagwiritsidwa ntchito kwambiri pochiza hypercholesterolemia, chikhalidwe chodziwika ndi kuchuluka kwa cholesterol m'magazi.Imagwira ntchito poletsa enzyme ya HMG-CoA reductase, yomwe imagwira ntchito yofunika kwambiri pakupanga cholesterol m'thupi.Pochepetsa kupanga mafuta a kolesterolini, Rosuvastatin imathandizira kuchepetsa kuchuluka kwa mafuta m'thupi, kuphatikizapo low-density lipoprotein (LDL) cholesterol, yomwe nthawi zambiri imatchedwa "cholesterol choipa". ndi njira yabwino.Imakhala ngati chomangira chomwe chimakhala ndi zochitika zingapo zamakina, zomwe zimapangitsa kuti pakhale zomangira zapadera komanso magulu ogwira ntchito omwe amafunikira kuti Rosuvastatin agwire ntchito yamankhwala. mapangidwe oyenera a mankhwala omaliza.Popanda ZD9, kaphatikizidwe ka Rosuvastatin sikukanatheka, ndikulepheretsa kupanga mankhwala ochepetsa cholesterol ofunikirawa.Imakhala ngati chomangira chomwe chimasinthidwa ndikusintha kwamankhwala kuti pamapeto pake apereke mankhwala omwe akugwira ntchito.Pochita gawo lofunikira popanga, ZD9 imathandizira pakupezeka kwa mankhwala ofunikira ochizira kuchuluka kwa cholesterol mwa odwala.