Zogulitsa

ATP-gated P2X3 receptors ndi ofunika transducers of nociceptive stimuli ndipo pafupifupi amangowonetsedwa ndi sensory ganglion neurons.Mu mouse trigeminal ganglion (TG), P2X3 receptor ntchito imakulitsidwa mosayembekezereka ndi pharmacological block of natriuretic peptide receptor-A (NPR-A), kufotokoza ntchito yomwe ingalepheretse ma peptides amtundu wa natriuretic mu nociception yomwe imayendetsedwa ndi P2X3 receptors.Kupanda kusintha kwa mapuloteni a P2X3 kukuwonetsa kusinthika kovutira komwe njira zake zochepetsera ntchito ya P2X3 receptor sizidziwika bwino. blocker anantin.Chifukwa chake, tidafufuza zosintha pakugawa kwa P2X3 receptor mu lipid raft membrane compartment, mawonekedwe awo a phosphorylation, komanso momwe amagwirira ntchito ndi chigamba.Kuchedwa kwa P2X3 deensitization inali njira imodzi yolimbikitsira ntchito ya P2X3 ya anantin.Anant pakugwiritsa ntchito adayambitsa kugawiranso kolandirira kwa P2X3 kuchipinda cha lipid raft ndikuchepetsa P2X3 serine phosphorylation, zochitika ziwiri zomwe sizinali zodalirana.Inhibitor ya cGMP-dependent protein kinase and siRNA-mediated knockdown ya BNP inatengera momwe anantin.Kuletsa kwa tonic kwa P2X3 receptor ntchito ndi BNP/NPR-A/PKG njira kumachitika kudzera m'njira ziwiri zosiyana: P2X3 serine phosphorylation ndi kugawanso ma receptor ku zipinda zopanda raft membrane.Njira yatsopanoyi yoyendetsera ma receptor ikhoza kukhala chandamale cha maphunziro amtsogolo omwe cholinga chake ndi kuchepetsa ntchito ya P2X3 receptor mu ululu wosatha.