Zogulitsa

Hyperkalemia panthawi ya renin-angiotensin-aldosterone system inhibition (RAAS-I) ingalepheretse mlingo woyenera.Njira zochizira ndi monga sodium polystyrene sulfonate potaziyamu kumanga utomoni, koma nkhawa chitetezo ndi kaphatikizidwe alipo, kuphatikizapo kugwirizana colonic necrosis (CN).Tidasanthula zamtengo wapatali wa odwala kunja ≥ zaka 18 zakubadwa omwe amalandila RAAS-I, yemwe anali ndi mbiri ya hyperkalemia kapena matenda a impso, omwe adalembedwa ndi sodium polystyrene sulfonate. kapena ongoyerekeza "mankhwala X" kumanga utomoni kwa aakulu hyperkalemia.Deta inapezedwa m'mabuku omwe analipo kale.Tinagwiritsa ntchito chitsanzo chowunikira zisankho ndi Monte Carlo probabilistic sensitivity kusanthula, kuchokera pamalingaliro olipira chithandizo chamankhwala komanso nthawi ya miyezi 12.Mitengo inayesedwa ndi madola aku US.Kuchita bwino kunayesedwa muzaka za moyo wosinthidwa bwino (QALYs), ndi kuchuluka kwa ndalama zogwiritsira ntchito ndalama (ICERs) . Mankhwala X sakanatha kuwononga ndalama zoposa $ 10.77 pa mlingo wa tsiku ndi tsiku kuti ukhale wotsika mtengo, pakufuna- kulipira ( WTP) malire a $ 50,000/QALY.Pa $ 40.00 pa mlingo watsiku ndi tsiku, mankhwala X adapeza chiŵerengero chamtengo wapatali cha $26,088,369.00 pa QALY iliyonse.Kusanthula kwa kukhudzika kwa njira imodzi kunawonetsa sodium polystyrene sulfonate kukhala njira yotsika mtengo pazochitika za CN ≤ 19.9%.Zochepa zimaphatikizapo chidziwitso chosakwanira pa zotsatira za odwala kunja ndi kusowa kwa deta mwachindunji kuyerekezera sodium polystyrene sulfonate ndi njira zina zomwe zingatheke.Njira zina sizingakhale zotsika mtengo pokhapokha ngati mtengo wofanana ndi sodium polystyrene sulfonate.Kusanthula uku kungawongolere zisankho zokhudzana ndi kukhazikitsidwa kwa njira zina zowongolera hyperkalemia, ndipo zikuwonetsa kuti sodium polystyrene sulfonate iyenera kugwiritsidwa ntchito ngati chiwongolero chokhazikika pamayesero azachipatala a othandizirawa.