Njira ya Poly-L-lysine ( 0.1%) Cas: 25988-63-0
| Nambala ya Catalog | XD90306 |
| Dzina lazogulitsa | Poly-L-lysine solution (0.1%) |
| CAS | 25988-63-0 |
| Molecular Formula | C18H38N6O4 |
| Kulemera kwa Maselo | 402.532124042511 |
| Zambiri Zosungira | 2-8 ° C |
Mafotokozedwe a Zamalonda
| Kuyesa | 0.1% |
| Maonekedwe | Madzi opanda mtundu |
Kusintha kwa eucine-rich repeat kinase 2 (LRRK2) ndizomwe zimadziwika kwambiri zomwe zimayambitsa matenda a Parkinson (PD).Zochitika zachipatala za LRRK2 PD sizidziwika ndi idiopathic PD, ndi kudzikundikira kwa α-synuclein ndi/kapena tau ndi/kapena ubiquitin mu intraneuronal aggregates.Izi zikusonyeza kuti LRRK2 ndiye chinsinsi chomvetsetsa etiology ya matendawa.Ngakhale kutayika kwa ntchito sikukuwoneka ngati njira yomwe imayambitsa PD kwa odwala a LRRK2, sizikudziwika bwino momwe puloteniyi imagwirizanirana ndi poizoni.Mu phunziro ili, timanena kuti LRRK2 yowonjezereka m'maselo ndi mu vivo imasokoneza ntchito ya njira ya ubiquitin-proteasome, ndipo izi zimapangitsa kuti zigawo zosiyanasiyana zikhale ndi LRRK2 overexpression.Tikuwonetsa kuti izi sizikulumikizidwa ndi magulu akulu a LRRK2 kapena kuthamangitsidwa kwa ubiquitin pazophatikizira.Chofunika kwambiri, zolakwika zotere sizikuwoneka ndi kuchulukitsidwa kwa mapuloteni okhudzana ndi LRRK1.Deta yathu ikuwonetsa kuti LRRK2 imalepheretsa kuchotsedwa kwa gawo lapansi la proteasome kumtunda kwa proteasome catalytic activation, ndikukomera kudzikundikira kwa mapuloteni ndi mapangidwe ophatikizika.Choncho, timapereka mgwirizano wa maselo pakati pa LRRK2, chifukwa chodziwika bwino cha PD, ndi phenotype yake yomwe yafotokozedwa kale ya kusonkhanitsa mapuloteni.
