N- (2-Acetamide) iminodiacetic asidi Cas: 26239-55-4 99% ufa woyera
| Nambala ya Catalog | XD90194 |
| Dzina lazogulitsa | ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Molecular Formula | C6H10N2O5 |
| Kulemera kwa Maselo | 190.15 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29241900 |
Mafotokozedwe a Zamalonda
| Fe | <5ppm |
| Pb | <5ppm |
| Kutaya pa Kuyanika | <0.5% |
| Phulusa la Sulfated | <0.1% |
| Maonekedwe | White ufa |
| Zosungunulira Zina | Palibe |
| Nthawi Yowonongeka (9g mu 91ml 1M NaOH, Kugwedeza kwa Magnetic) | <1 min |
| A300 ( 9% mu 1 M NaOH) | <0.08% |
| Chiwerengero cha malekezero Owonedwa mu kapindika ka titration | Awiri okha |
| pH Range yomwe Imatanthauzira Titration Second Endpoint | 9.1 - 10.1 |
| Kusungunuka (9% mu 1M NaOH) | Zomveka komanso Zopanda Mtundu |
| Tsiku lopanga | |
| Madzi KF | <1% |
| Kuyesa (Titration) pazowuma | > 99.0% |
| Infuraredi | Zimagwirizana |
Nucleoside adenosine imagwira ntchito zamanjenje ndi zamtima kudzera pa A2A receptor (A2AR).Poyankha kuchuluka kwa okosijeni m'matenda, ndende ya adenosine plasma imayendetsedwa makamaka kudzera mu kaphatikizidwe kake ndi CD73 komanso kudzera pakuwonongeka kwake ndi adenosine deaminase (ADA).Ma cell-surface endopeptidase CD26 imayang'anira kuchuluka kwa vasoactive ndi antioxidant peptides motero imayang'anira kagayidwe ka okosijeni ku minofu ndi kuyankha kwa oxidative kupsinjika.Ngakhale kuchulukitsidwa kwa adenosine, CD73, ADA, A2AR, ndi CD26 poyankha hypoxia kumalembedwa bwino, zotsatira za hyperoxic ndi hyperbaric mikhalidwe pazinthu izi ziyenera kuganiziridwanso.Makoswe ndi mzere wa cell wa murine Chem-3 womwe umasonyeza A2AR unawonetsedwa ku 0.21 bar O2, 0.79 bar N2 (padziko lapansi; normoxia);1 bar O2 (hyperoxia);2 bar O2 (hyperbaric hyperoxia);0.21 bar O2, 1.79 bar N2 (hyperbaria).Adenosine plasma concentration, CD73, ADA, A2AR expression, ndi CD26 ntchito zinayankhulidwa mu vivo, ndipo kupanga cAMP kunayankhulidwa mu cellulo.Pakuti mu vivo mikhalidwe, 1) hyperoxia inachepetsa mlingo wa adenosine plasma ndi T cell pamwamba pa CD26 ntchito, pamene inawonjezera CD73 kufotokoza ndi ADA mlingo;2) hyperbaric hyperoxia imakonda kukulitsa chikhalidwe;ndi 3) hyperbaria yokha inalibe mphamvu yaikulu pazigawo izi.Mu ubongo ndi mu cellulo, 1) hyperoxia inachepetsa mawu a A2AR;2) hyperbaric hyperoxia imakulitsa chikhalidwe;ndi 3) hyperbaria yokha inasonyeza mphamvu kwambiri.Tinapeza njira yofananira yokhudzana ndi kaphatikizidwe ka A2AR mRNA muubongo ndi kupanga kwa cAMP m'maselo a Chem-3.Chifukwa chake mulingo wapamwamba wa okosijeni umakonda kutsitsa njira ya adenosinergic ndi ntchito za CD26.Hyperbaria yokha inakhudza kufotokozera kwa A2AR kokha ndi kupanga kwa cAMP.Timakambirana momwe njira zotere zomwe zimayambitsidwa ndi hyperoxygenation zimatha kuchepetsa, kudzera mu vasoconstriction, kuperekera kwa okosijeni ku minofu ndi kupanga mitundu ya okosijeni yokhazikika.
