Zogulitsa

The europium(III) ndi terbium(III) complexes, monga [Eu(dpq)(DMF)2(NO3)3] (1), [Eu(dppz)2(NO3)3] (2), [Tb(dpq) )(DMF)2Cl3] (3), ndi [Tb(dppz)(DMF)2Cl3] (4), kumene dipyrido[3,2-d:2',3'-f]quinoxaline (dpq mu 1 ndi 3) , dipyrido[3,2-a: 2',3'-c]phenazine (dppz mu 2 ndi 4) ndi N, N'-dimethylformamide (DMF) akhala akudzipatula, omwe amadziwika ndi deta yawo ya physicochemical, maphunziro a luminescence ndi kuyanjana kwawo. ndi DNA, serum albumin protein ndi DNA cleavage yopangidwa ndi zithunzi imawerengedwa.Ma X-ray crystal ma complexes 1-4 amasonyeza ma discrete mononuclear Ln (3+)-based structures.The Eu(3+) ku [Eu(dpq)(DMF)2(NO3)3] (1) ndi [Eu(dppz)2(NO3)3] (2) monga [Eu(dppz)2(NO3)3) ] · dppz (2a) imatengera kamangidwe ka dodecahedron kamene kamapangidwa ndi bidentate N,N-donor dpq ligand, DMF ziwiri ndi ma anion atatu NO3(-) mu 1 ndi ma bidentate awiri a N,N-donor dppz ligand ndi atatu NO3( -) anions mu 2. Complexes 3 ndi 4 amasonyeza seveni-coordinated mono-capped octahedron structure pomwe Tb(3+) ili ndi bidentate dpq/dppz ligands, DMF awiri ndi atatu Cl(-) anions.Malowa ndi owala kwambiri mwachilengedwe zomwe zikuwonetsa kusamutsa kwamphamvu kwa chithunzi kuchokera ku dpq/dppz mlongoti kupita ku Ln(3+) kuti apange malo osangalatsa omwe amakhalapo kwanthawi yayitali pakusintha kwa f → f.Mawonekedwe a luminescence okhazikika nthawi ya ma complexes 1-4 akuwonetsa magulu ang'onoang'ono omwe amapangidwa ndi (5)D0 → (7)F(J) ndi (5)D4 → (7)F(J) ff kusintha kwa Eu(3) +) ndi Tb(3+) ions motsatana.Chiwerengero cha mamolekyu amadzi amkati (q) adatsimikiziridwa kuchokera ku miyeso ya moyo wa luminescence mu H2O ndi D2O kutsimikizira kusinthana kwa ligand ndi madzi mu njira.Macomplexes amawonetsa chidwi chomangirira ku CT-DNA yopereka zomangira zokhazikika mumitundu ya 1.0 × 10(4) -6.1 × 10(4) M(-1) mu dongosolo 2, 4 (dppz)> 1, 3 (dpq).Zomwe zimamanga za DNA zikuwonetsa kuti DNA groove imamanga ndi kuphatikizika pang'ono kwa ma complex.Ma complexes onse amawonetsanso kukhazikika (K(BSA) ~ 10(5) M(-1)) ku protein ya bovine serum albumin (BSA).Kuchuluka kwa ma luminescence spectral band omwe ali ndi nthawi yayitali kumawonjezeka kwambiri ndi kuchuluka kwa DNA mu sing'anga yamadzimadzi chifukwa cha kusamuka kwa madzi akamalumikizana ndi DNA, motero kumachepetsa kuzimitsa kosatulutsa ma radiation kudzera mu oscillator ya OH.Complexes 1-4 mogwira mtima amaphatikizira supercoiled (SC) ds-DNA ku mawonekedwe ake ozungulira (NC) atakumana ndi UV-A kuwala kwa 365 nm popanga singlet oxygen ((1)O2) ndi hydroxyl radicals (HO˙) monga mitundu yokhazikika ya okosijeni pazambiri za micromolar pansi pazikhalidwe za thupi.