Zogulitsa

Linagliptin Intermediate F, yomwe imadziwikanso kuti 3-aminopiperidine-1-carboxylic acid, ndi mankhwala ofunikira pakuphatikizika kwa linagliptin, mankhwala omwe amagwiritsidwa ntchito pochiza matenda amtundu wa 2 mellitus.Linagliptin ndi m'gulu la mankhwala omwe amadziwika kuti dipeptidyl peptidase-4 (DPP-4) inhibitors, omwe amathandiza kuwongolera kuchuluka kwa shuga m'magazi.Imagwira ntchito ngati chomangira chomangira chapadera cha linagliptin pochita zinthu zingapo.Chapakatikatichi chimagwiritsidwa ntchito makamaka popanga mphete ya piperidine ya ma cell a linagliptin. Likapangidwa, linagliptin limagwira ntchito poletsa ntchito ya enzymatic ya DPP-4.DPP-4 inhibitors amagwira ntchito poletsa kuwonongeka kwa mahomoni a incretin, monga glucagon-like peptide-1 (GLP-1), omwe amachititsa kuti insulini itulutsidwe komanso kupondereza katulutsidwe ka glucagon.Poletsa DPP-4, linagliptin imatalikitsa kugwira ntchito kwa ma incretin mahomoniwa, zomwe zimapangitsa kuti shuga asamayende bwino mwa anthu omwe ali ndi matenda a shuga amtundu wa 2. Linagliptin amalembedwa ngati chothandizira pazakudya komanso kuchita masewera olimbitsa thupi polimbana ndi matenda amtundu wa 2.Amadziwika ndi theka la moyo wautali, womwe umalola kuti kamodzi patsiku kukhale kosavuta.Linagliptin awonetsa kuti amachepetsa hemoglobin A1c, chizindikiro cha kuwongolera shuga kwa nthawi yayitali, ndipo nthawi zambiri amalekerera bwino odwala. zomwe zitha kukhudza kwambiri miyoyo ya anthu omwe ali ndi matenda amtundu wa 2.Pothandizira kupanga kapangidwe kake kake ka linagliptin, chapakati ichi chimathandizira kuti chomalizacho chitsekeretse DPP-4 ndikuwongolera glycemic control. amagwiritsidwa ntchito pochiza matenda a shuga a 2.Udindo wake pakupanga kapangidwe ka maselo a linagliptin umatsimikizira kufunika kwake popanga mankhwala omwe amatha kusintha kuwongolera shuga m'magazi ndikuwongolera kasamalidwe ka matenda a shuga.Poletsa DPP-4, linagliptin imathandizira kuwongolera kuchuluka kwa shuga m'magazi ndikuthandizira kukhala ndi moyo wabwino kwa anthu omwe ali ndi matenda amtundu wa 2.