L-Tryptophan Cas: 73-22-3 99% ufa woyera
| Nambala ya Catalog | XD90295 |
| Dzina lazogulitsa | L-Tryptophan |
| CAS | 73-22-3 |
| Molecular Formula | Chithunzi cha C11H12N2O2 |
| Kulemera kwa Maselo | 204.22518 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29339980 |
Mafotokozedwe a Zamalonda
| Kuyesa | 99% mphindi |
| Maonekedwe | White ufa |
| Gulu | Chithunzi cha USP32 |
| Kuzungulira kwachindunji | -29.4 mpaka -32.8 |
| pH | 5.5 mpaka 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Kutaya pa Kuyanika | <0.3% |
| Zotsalira pa Ignition | 0.1% kuchuluka |
| Cl | 0.05% kuchuluka |
Indoleamine 2,3-dioxygenase (IDO1) ndi tryptophan 2,3-dioxygenase (TDO) ndi ma enzyme awiri osiyana omwe ali ndi magawo osiyana a minofu ndi maudindo a thupi, koma onse amathandizira kutembenuka kwa tryptophan kukhala N-formylkynurenine (NFK).IDO1 yatsimikiziridwa kuti ndi mankhwala ang'onoang'ono a khansa ya khansa, pamene kafukufuku wachipatala amasonyeza kuti TDO ikhoza kukhala chandamale cha khansa ya immunotherapy ndi matenda a neurodegenerative.Tapanga kuyesa kwapamwamba kwambiri kwa IDO1 ndi TDO kutengera kafukufuku wamankhwala, NFK Green, omwe amalumikizana mwachindunji ndi NFK kuti apange molekyulu yobiriwira ya fulorosenti yokhala ndi kutalika kosangalatsa kwa 400 nm ndi kutalika kwa 510 nm.Timapereka kufananitsa koyamba ndi mbali kwa ma inhibitors angapo omwe adasindikizidwa a IDO1 ndi TDO ndikuwonetsa kuti preclinical IDO1 inhibitor Compound 5l ikuwonetsa kuyanjana kwakukulu ndi TDO, pomwe kusankhidwa kwachibale kwa zoletsa zina zosindikizidwa zidatsimikizika.Kuyenerera pakuwunika kwapamwamba kwa zoyesererazo kudawonetsedwa poyang'ana laibulale yamankhwala 87,000 mumtundu wa 384- kapena 1536-chitsime.Pomaliza, tikuwonetsa kuti kuyezetsako kungagwiritsidwenso ntchito kuyeza kuchuluka kwa maselo kuti agwiritse ntchito tryptophan ndikuyesa mphamvu zama cell a IDO1 ndi TDO inhibitors.
