Zogulitsa

Zotsatira za pharmacological za theanine

1. Zotsatira za dongosolo la mitsempha

Poyesa mphamvu ya theanine pa metabolism ya monoamines m'madera osiyanasiyana a ubongo, Heng Yue et al.adapeza kuti theanine imatha kulimbikitsa kwambiri kutulutsidwa kwa dopamine muubongo wapakati ndikuwongolera magwiridwe antchito a dopamine muubongo.Dopamine ndi neurotransmitter yapakati yomwe imayendetsa ma cell a minyewa yaubongo, ndipo zochitika zake zakuthupi zimagwirizana kwambiri ndi momwe munthu amamvera.Ngakhale limagwirira ntchito theanine chapakati mantha dongosolo la ubongo si bwino.Koma zotsatira za theanine pa mzimu ndi kutengeka mosakayikira ndi zina kuchokera ku zotsatira za zochitika za thupi lapakati pa neurotransmitter dopamine.Zoonadi, zotsutsana ndi kutopa kwa kumwa tiyi zimakhulupiliranso kuti zimachokera ku izi mpaka pamlingo wina.

Muzoyesera zawo zina, Yokogoshi et al.adatsimikizira kuti kutenga theanine kudzakhudza mwachindunji ntchito ya serotonin yapakati ya neurotransmitter mu ubongo yokhudzana ndi kuphunzira ndi kukumbukira.

2. Antihypertensive zotsatira

Nthawi zambiri amakhulupirira kuti kuwongolera kwa kuthamanga kwa magazi kwa anthu kumakhudzidwa ndi kutulutsa kwapakati ndi zotumphukira za neurotransmitters catecholamine ndi serotonin.Kafukufuku wasonyeza kuti theanine akhoza kuchepetsa mowiriza matenda oopsa mu makoswe.Kimura et al.ankakhulupirira kuti mphamvu ya antihypertensive ya theanine ingabwere kuchokera ku kayendetsedwe ka katulutsidwe ka serotonin yapakati mu ubongo.

Mphamvu ya hypotensive yowonetsedwa ndi theanine imatha kuwonedwanso ngati yokhazikika pamlingo wina.Ndipo kukhazikika kumeneku mosakayika kudzathandiza kubwezeretsa kutopa kwakuthupi ndi m'maganizo.

3. Zimakhudza kukumbukira

Chu et al.adanena kuti adapeza ku Operanttest (kuyesera kwa zinyama komwe chakudya chimaperekedwa pamodzi ndi kusintha kwa kuwala) kafukufuku ndipo anapeza kuti makoswe opatsidwa 180 mg wa theanine pakamwa tsiku lililonse anali ndi luso lophunzira bwino poyerekeza ndi gulu lolamulira.kusintha kwina.Kuphatikiza apo, pophunzira mayeso a Avoidance (kuyesa kukumbukira nyama komwe nyama zidzalandira kugwedezeka kwamagetsi m'chipinda chamdima zikalowa m'chipinda chamdima ndi chakudya chochokera kuchipinda chowala), zimatsimikiziranso kuti theanine imatha kukulitsa luso la kukumbukira. za makoswe.Kafukufuku wambiri watsimikizira kuti zotsatira za theanine pakuwongolera kuphunzira ndi kukumbukira ndi zotsatira za kuyambitsa ma neurotransmitters apakati.

4. Phunzitsani maganizo ndi thupi lanu

Kumayambiriro kwa 1975, Kimura et al.inanena kuti theanine akhoza kuchepetsa chapakati hyperexcitability chifukwa caffeine.Ngakhale kuti caffeine m’masamba a tiyi ndi yocheperapo poyerekezera ndi khofi ndi koko, kupezeka kwa theanine kumathandiza anthu kusangalala ndi mpumulo akamamwa tiyi amene khofi ndi koko alibe.

Monga tonse tikudziwira, mitundu inayi ya mafunde a ubongo, α, β, σ ndi θ, omwe ali ogwirizana kwambiri ndi thupi ndi maganizo a anthu, akhoza kuyezedwa pamwamba pa ubongo wathu.Pamene Chu et al.anawona zotsatira za theanine pa mafunde aubongo a atsikana achichepere a 15 azaka zapakati pa 18 mpaka 22, adapeza kuti α-wave inali ndi chiwonjezeko chachikulu pambuyo poyendetsa pakamwa pa theanine kwa mphindi 40.Koma pansi pa mikhalidwe yoyesera yofananayo, sanapeze zotsatira za theanine pa theta-wave ya kugona kulamulira.Kuchokera pazotsatirazi, amakhulupirira kuti kutsitsimula kwakuthupi ndi m'maganizo komwe kumayambitsidwa ndi kutenga theanine sikupangitsa kuti anthu azigona, koma kuwongolera ndende.

5. Chakudya chopatsa thanzi

Zambiri mwazakudya zomwe zimagulitsidwa pamsika ndi zopewera kapena kukonza matenda akuluakulu.Chakudya chathanzi monga theanine chomwe sichiri chogodomalitsa, komanso chimachepetsa kutopa, chimachepetsa kuthamanga kwa magazi ndikuwongolera kuphunzira komanso kukumbukira ndizovuta komanso zopatsa chidwi.Pazifukwa izi, theanine adapambana mphotho ya dipatimenti yofufuza pa International Food Raw Materials Conference yomwe idachitika ku Germany mu 1998.

Theanine ndi amino acid yomwe ili ndi tiyi wambiri, yomwe imakhala yoposa 50% ya ma amino acid aulere ndi 1% -2% ya kulemera kowuma kwa masamba a tiyi.Theanine ndi thupi loyera ngati singano, losungunuka mosavuta m'madzi.Ili ndi kukoma kokoma komanso kotsitsimula ndipo ndi gawo la kukoma kwa tiyi.Anthu aku Japan nthawi zambiri amagwiritsa ntchito shading kuti awonjezere zomwe zili mu theanine m'masamba a tiyi kuti masamba a tiyi akhale atsopano.

(1) Mayamwidwe ndi metabolism.

Pambuyo pakamwa makonzedwe a theanine m'thupi la munthu, amatengeka ndi matumbo a m'malire mucosa, amalowa m'magazi, ndipo amamwazikana kupita ku ziwalo ndi ziwalo kudzera m'magazi, ndipo gawo lina limatulutsidwa mumkodzo pambuyo povunda. impso.Kuchuluka kwa theanine komwe kumalowetsedwa m'magazi ndi chiwindi kudachepa pakatha ola limodzi, ndipo theanine muubongo idafika patali kwambiri patatha maola asanu.Pambuyo pa maola 24, theanine m'thupi la munthu idasowa ndipo idatulutsidwa ngati mkodzo.

(2) Sinthani kusintha kwa ma neurotransmitters muubongo.

Theanine imakhudza kagayidwe kachakudya ndi kutulutsidwa kwa ma neurotransmitters monga dopamine mu ubongo, ndipo matenda aubongo omwe amayendetsedwa ndi ma neurotransmitters awa amathanso kuyendetsedwa kapena kupewedwa.

(3) Kukulitsa luso la kuphunzira ndi kukumbukira.

Pazoyeserera zanyama, zidapezekanso kuti luso lophunzirira komanso kukumbukira mbewa zomwe zimatenga theanine zinali zabwinoko kuposa za gulu lolamulira.Pazoyeserera zanyama, zidapezeka kuti luso lophunzirira lidayesedwa atatenga theanine kwa miyezi 3-4.Zotsatira zoyesa zidawonetsa kuti kuchuluka kwa dopamine kwa mbewa zomwe zimatenga theanine kunali kwakukulu.Pali mitundu yambiri ya mayeso a luso la kuphunzira.Chimodzi ndicho kuika mbewa m’bokosi.M'bokosi muli kuwala.Nyali ikayaka, kanikizani switch ndipo chakudya chidzatuluka.Makoswe omwe amatenga theanine amatha kudziwa zofunikira pakanthawi kochepa, ndipo luso la kuphunzira ndi lalikulu kuposa la mbewa zomwe sizimamwa theanine.Chachiwiri ndi kupezerapo mwayi pa chizolowezi cha mbewa chobisala mumdima.Khosweyo ikathamangira mumdima, imadabwa ndi kugwedezeka kwamagetsi.Makoswe omwe amatenga theanine amakonda kukhala pamalo owala kuti asagwedezeke ndi magetsi, zomwe zikuwonetsa kuti ndizowopsa kumalo amdima.kukumbukira mwamphamvu.Zitha kuwoneka kuti theanine imakhala ndi mphamvu yopititsa patsogolo kukumbukira komanso kuphunzira kwa mbewa.

(4) sedative zotsatira.

Kafeini ndi mankhwala odziwika bwino, komabe anthu amakhala omasuka, odekha, komanso osangalala akamamwa tiyi.Zatsimikiziridwa kuti izi ndizo makamaka zotsatira za theanine.Kudya munthawi yomweyo kwa caffeine ndi ma amino acid kumalepheretsa chisangalalo.

(5) Kupititsa patsogolo matenda a msambo.

Azimayi ambiri ali ndi matenda a msambo.Msambo syndrome ndi chizindikiro cha maganizo ndi thupi kusapeza mu akazi a zaka 25-45 mu 3-10 masiku pamaso msambo.M'maganizo, makamaka amawonetseredwa ngati kukwiya msanga, kukwiya, kupsinjika maganizo, kusakhazikika, kulephera kuika maganizo, etc. Mwathupi, makamaka amawonetseredwa ngati kutopa kosavuta, kugona, kupweteka mutu, kupweteka pachifuwa, kupweteka kwa m'mimba, kupweteka kwa msana, manja ozizira komanso mapazi, etc. The sedative zotsatira za theanine zimabweretsa m'maganizo ake amaliorating zotsatira pa msambo syndrome, amene anasonyeza m'mayesero azachipatala akazi.

(6) Tetezani maselo a minyewa.

Theanine imatha kulepheretsa kufa kwa maselo amitsempha chifukwa cha kusakhalitsa kwa ubongo, komanso kumateteza maselo amitsempha.Imfa ya ma cell a minyewa imagwirizana kwambiri ndi excitatory neurotransmitter glutamate.Kufa kwa maselo kumachitika pamaso pa glutamate yochuluka, yomwe nthawi zambiri imayambitsa zinthu monga Alzheimer's.Theanine imakhala yofanana ndi glutamic acid ndipo idzapikisana ndi malo omwe amamangiriza, motero amalepheretsa kufa kwa mitsempha.Theanine ingagwiritsidwe ntchito pochiza ndi kupewa matenda a ubongo omwe amayamba chifukwa cha glutamate, monga cerebral embolism, cerebral embolism, cerebral hemorrhage ndi zina za ubongo, komanso matenda monga kuchepa kwa magazi ndi kusokonezeka kwa ubongo komwe kumachitika pa opaleshoni ya ubongo kapena kuvulala kwa ubongo.

(7) Zotsatira za kutsitsa magazi.

Poyesera nyama, jekeseni theanine mu makoswe othamanga kwambiri, kuthamanga kwa magazi kwa diastolic, kuthamanga kwa magazi kwa systolic ndi kuthamanga kwa magazi kunachepetsedwa, ndipo kuchepetsa kuchepa kunali kogwirizana ndi mlingo, koma panalibe kusintha kwakukulu kwa mtima;theanine inali yothandiza pa makoswe abwinobwino a kuthamanga kwa magazi.Panalibe zotsatira zochepetsera kuthamanga kwa magazi, kusonyeza kuti theanine anali ndi mphamvu yochepetsera magazi pa makoswe oopsa.Theanine imatha kuchepetsa kuthamanga kwa magazi powongolera kuchuluka kwa ma neurotransmitters muubongo.

(8) Kupititsa patsogolo mphamvu ya mankhwala oletsa khansa.

Matenda a khansa ndi imfa zidakalipobe, ndipo mankhwala opangidwa kuti athetse khansa nthawi zambiri amakhala ndi zotsatirapo zamphamvu.Pochiza khansa, kuphatikizapo kugwiritsa ntchito mankhwala osokoneza bongo, mankhwala osiyanasiyana omwe amalepheretsa zotsatira zawo ayenera kugwiritsidwa ntchito nthawi imodzi.Theanine palokha alibe odana ndi chotupa ntchito, koma akhoza kusintha ntchito zosiyanasiyana odana ndi chotupa mankhwala.Mankhwala a theanine ndi odana ndi chotupa akagwiritsidwa ntchito limodzi, theanine amatha kuletsa mankhwala odana ndi chotupa kuti asatuluke m'maselo a chotupa ndikuwonjezera mphamvu yotsutsa khansa yamankhwala odana ndi chotupa.Theanine imathanso kuchepetsa zotsatira za mankhwala a antineoplastic, monga kulamulira mlingo wa lipid peroxidation, kuchepetsa zotsatira zake monga kuchepa kwa maselo oyera a magazi ndi mafupa a mafupa omwe amayamba chifukwa cha mankhwala a antineoplastic.Theanine imakhalanso ndi zotsatira zolepheretsa kulowa kwa maselo a khansa, yomwe ndi njira yofunikira kuti maselo a khansa afalikire.Kulepheretsa kulowa kwake kumalepheretsa khansa kufalikira.

(9) Kuchepetsa thupi

Monga tonse tikudziwa, kumwa tiyi kumakhala ndi zotsatira zochepetsera thupi.Kumwa tiyi kwa nthawi yayitali kumapangitsa anthu kuwonda ndikuchotsa mafuta a anthu.Kuchepetsa thupi kwa tiyi ndi chifukwa cha kuphatikizika kwa magawo osiyanasiyana a tiyi, kuphatikiza theanine, yomwe imathandizira kuchepetsa cholesterol m'thupi.Kuphatikiza apo, theanine yapezekanso kuti ili ndi chitetezo cha chiwindi komanso antioxidant zotsatira.Chitetezo cha theanine chatsimikiziridwanso.

(10) Anti-kutopa zotsatira

Kafukufuku wapeza kuti theanine ili ndi zotsutsana ndi kutopa.Kuwongolera pakamwa kwa mitundu yosiyanasiyana ya theanine kwa mbewa kwa masiku 30 kumatha kutalikitsa nthawi yosambira yolemera kwambiri ya mbewa, kuchepetsa kumwa kwa glycogen m'chiwindi, komanso kuchepetsa kuchuluka kwa urea nayitrogeni wa seramu chifukwa cha masewera olimbitsa thupi;imakhudza kwambiri kuchuluka kwa magazi a lactate mu mbewa pambuyo pochita masewera olimbitsa thupi.Ikhoza kulimbikitsa kuchotsa lactate ya magazi pambuyo pochita masewera olimbitsa thupi.Chifukwa chake, theanine imakhala ndi anti-kutopa kwenikweni.Makinawa atha kukhala okhudzana ndi kuti theanine imatha kuletsa kutulutsa kwa serotonin ndikulimbikitsa kutulutsa kwa catecholamine (5-hydroxytryptamine ili ndi zoletsa pakatikati pa mitsempha, pomwe catecholamine imakhala ndi chisangalalo).

(11) Kupititsa patsogolo chitetezo chaumunthu

Kuyesera komwe kunamalizidwa posachedwapa ndi yunivesite ya Harvard ku United States kunasonyeza kuti tiyi wobiriwira, tiyi wa oolong ndi tiyi zimakhala ndi magulu ambiri a amino, omwe amatha kupititsa patsogolo mphamvu zogwirira ntchito za maselo a chitetezo cha mthupi komanso kumapangitsa kuti thupi la munthu likhale ndi mphamvu zolimbana ndi matenda opatsirana.

Kugwiritsa ntchito theanine m'munda wa chakudya

Kale mu 1985, US Food and Drug Administration idazindikira theanine ndikutsimikizira kuti theanine yopangidwa nthawi zambiri imadziwika kuti ndi chinthu chotetezeka (GRAS), ndipo palibe choletsa pakugwiritsa ntchito pakugwiritsa ntchito.

(1) Zowonjezera zakudya zogwira ntchito: Theanine ali ndi ntchito zowonjezera mphamvu ya mafunde a alpha mu ubongo, kupangitsa anthu kukhala omasuka komanso kukumbukira bwino, ndipo adadutsa mayesero aumunthu.Choncho, zikhoza kuwonjezeredwa ku chakudya monga chogwiritsira ntchito kuti mukhale ndi chakudya chogwira ntchito chomwe chimachepetsa nkhawa zamanjenje komanso kuwongolera nzeru.Kafukufuku watsimikiziranso kuti theanine ikhoza kuwonjezeredwa ku maswiti, zakumwa zosiyanasiyana, ndi zina zotero kuti mupeze zotsatira zabwino zotsitsimula.Panopa Japan ikugwira ntchito yofufuza ndi chitukuko m'derali.

(2) Kuwongolera kwabwino kwa zakumwa za tiyi

Theanine ndiye chigawo chachikulu cha kukoma kwatsopano komanso kotsitsimula kwa tiyi, komwe kumatha kulepheretsa kuwawa kwa tiyi komanso kuwawa kwa tiyi polyphenols.Pakalipano, chifukwa cha kuchepa kwa zipangizo zamakono komanso zamakono zamakono, kukoma kwatsopano komanso kotsitsimula kwa zakumwa za tiyi m'dziko langa ndizovuta.Chifukwa chake, muzakumwa za tiyi Kuonjezera kuchuluka kwa theanine panthawi yakukula kumatha kusintha kwambiri zakumwa za tiyi komanso kukoma kwake.Chakumwa cha "tiyi waiwisi" chomwe chinapangidwa kumene ndi Kampani ya Kirin yaku Japan chikuwonjezeredwa ndi theanine, ndipo kupambana kwake kwakukulu pamsika wa zakumwa zaku Japan ndi chitsanzo.

(3) Kuwongolera kwabwino

Theanine sangagwiritsidwe ntchito ngati chosintha chowonjezera cha tiyi wobiriwira, komanso amatha kuletsa kuwawa ndi kupwetekedwa mtima muzakudya zina, kuti apititse patsogolo kukoma kwa chakudya.Zakumwa za koko ndi tiyi wa balere zimakhala ndi zowawa zapadera kapena zokometsera, ndipo chokometsera chowonjezera chimakhala ndi kukoma kosasangalatsa.Ngati 0.01% theanine igwiritsidwa ntchito m'malo mwa sweetener, zotsatira zake zikuwonetsa kuti kukoma kwa chakumwa chophatikizidwa ndi theanine kumatha kusintha kwambiri.zakusintha.

(3) Mapulogalamu m'madera ena

Theanine angagwiritsidwe ntchito ngati madzi oyeretsa kuyeretsa madzi akumwa;Kugwiritsiridwa ntchito kwa theanine monga chogwiritsira ntchito mu deodorant kwanenedwa mu ma patent aku Japan.Patent ina imanenanso kuti chinthu chokhala ndi theanine chigawo chimodzi chitha kulepheretsa kudalira pamalingaliro.Theanine amagwiritsidwa ntchito ngati moisturizer mu zodzoladzola komanso monga chakudya chonyowa pakhungu.