L-Glutamine Cas: 56-85-9 99% ufa woyera
| Nambala ya Catalog | XD90309 |
| Dzina lazogulitsa | L-Glutamine |
| CAS | 56-85-9 |
| Molecular Formula | Chithunzi cha C5H10N2O3 |
| Kulemera kwa Maselo | 146.1445 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29241900 |
Mafotokozedwe a Zamalonda
| Kutentha Kosungirako | +20 C |
| Kulemera kwa Maselo | 146.14 |
| Kuyesa | 99.0% mphindi |
| Maonekedwe | White ufa |
1.Early T-cell precursor leukemia (ETP-ALL) ndi gawo laling'ono lachiwopsezo cha khansa ya m'magazi ya anthu yomwe imamveka bwino pamlingo wa maselo.Apa tikunena za kusuntha komwe kumayang'ana chala cha zinc E-box-binding transcript factor ZEB2 ngati chotupa chobwerezabwereza mu immature/ETP-ALL.Pogwiritsa ntchito mbewa yokhazikika yogwira ntchito, tikuwonetsa kuti mawu osasunthika a Zeb2 amayambitsa T-cell leukemia.Kuphatikiza apo, leukemia yoyendetsedwa ndi mbewa ya Zeb2 imawonetsa zinthu zina za siginecha ya jini yamunthu/ETP-ALL, komanso kuthekera koyambitsa khansa ya m'magazi ndikuyambitsa Janus kinase (JAK)/ma transducer ndi ma activator of transcript (STAT) kutsegulira kwa IL7R.Kafukufukuyu akuwulula ZEB2 ngati oncogene mu biology of immature/ETP-ALL ndipo amatsegula njira yopita ku maphunziro azachipatala azinthu zatsopano zochizira mtundu waukali wa T-ALL wamunthu pogwiritsa ntchito mbewa yathu yoyendetsedwa ndi Zeb2.
2.Pluripotency, kudzikonzanso, ndi kusiyanitsa ndizopadera za maselo a embryonic stem (ES), motero amapereka malingaliro ofunikira mu mankhwala obwezeretsa.Njira zachitukuko zimafuna bungwe lokonzekera bwino, makamaka loyendetsedwa ndi njira zodziwika bwino za JAK/STAT, PI3K/AKT, ndi ERK/MAPK.SPREDs (mapuloteni okhudzana ndi kukula ndi EVH1 domain) adapezeka ngati zoletsa njira yowonetsera ERK / MAPK, pamene palibe chomwe chimadziwika ponena za ntchito zawo m'maselo a ES komanso panthawi yosiyanitsidwa koyambirira, mpaka pano.Tinapanga SPRED1 ndi SPRED2 overexpressing ndi SPRED2 knockout murine ES maselo kuti afufuze ntchito za mapuloteni a SPRED m'maselo a ES komanso pakusiyanitsa koyambirira.Kufotokozera kwakukulu kwa SPREDs kumawonjezera kwambiri kudzikonzanso ndi clonogenicity ya murine ES maselo, pamene kusowa kwa SPRED2 kumachepetsa kufalikira ndikuwonjezera apoptosis.Pakusiyanitsidwa koyambirira kwa matupi a embyoid, ma SPRED amalimbikitsa mkhalidwe wa pluripotent ndikuletsa kusiyanitsa komwe mesodermal d inferentiation mu cardiomyocytes imachedwa ndikuletsedwa.LIF- ndi kukula factor-stimulation anasonyeza kuti SPREDs amaletsa ERK/MAPK kutsegula mu murine ES maselo.Komabe, palibe zotsatira zomwe zimawoneka pa LIF-induced activation ya JAK / STAT3, kapena PI3K / AKT yowonetsera njira ndi mapuloteni a SPRED. Njira yozindikiritsira ya MAPK m'maselo a pluripotent.
