Mankhwala a Furazolidone: 67-45-8
| Nambala ya Catalog | XD91885 |
| Dzina lazogulitsa | Mankhwala "Furazolidone". |
| CAS | 67-45-8 |
| Fomu ya Molecularla | C8H7N3O5 |
| Kulemera kwa Maselo | 225.16 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 29349990 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Yellow powder |
| Asay | 99% mphindi |
| Malo osungunuka | 254-256°C (dec.) |
| Malo otentha | 366.66°C (kuyerekeza molakwika) |
| kachulukidwe | 1.5406 (kuyerekeza movutikira) |
| refractive index | 1.7180 (chiyerekezo) |
| Fp | 2 °C |
| kusungunuka | asidi formic: soluble50mg/mL |
| pka | -1.98±0.20(Zonenedweratu) |
| Zomverera | Kuwala Kumverera |
| λ max | 365nm (DMSO) (lit.) |
| Kukhazikika | Wokhazikika.Zoyaka.Zosagwirizana ndi ma oxidizing amphamvu. |
Ma antibacterial spectrum a furazolidone ndi ofanana ndi a furazolidone.Monga mankhwala oletsa matenda, ndi othandiza pochiza Salmonella, Shigella, Escherichia coli, Proteus, Streptococcus, ndi Staphylococcus aureus.Tizilombo toyambitsa matenda sizovuta kukhala ndi mankhwala osamva mankhwala.Komanso ilibe kutsutsana ndi maantibayotiki a gulu la sulfa.Amagwiritsidwa ntchito pochiza matenda a kamwazi, enteritis, typhoid, paratyphoid ndi apakhungu mankhwala a nyini trichomoniasis.
2. Mankhwalawa ndi fungicide omwe ali ndi antibacterial yotakata.Monga mankhwala odana ndi matenda, ndi othandiza pochiza mabakiteriya osiyanasiyana a Gram-positive ndi negative kuphatikizapo Escherichia coli, Bacillus anthracis, ndi Paratyphoid bacilli.Sizothandiza kokha pochiza kamwazi, enteritis, komanso kugwiritsidwa ntchito pochiza matenda a nyini.M'zaka zaposachedwapa, ali ndi efficacy zabwino zochizira typhoid fever.Monga chowonjezera cha mankhwala ndi zakumwa za nyama, imakhala ndi antibacterial yapadera pa Salmonella, Escherichia coli ndi Salmonella pullorum komanso imakhala ndi zoletsa zina pa protozoa (mabakiteriya a coccidia, ndi zina zotero) ndipo amawapangitsa kuti asayambe kusinthasintha mankhwala.Kuchuluka kwa furazolidone kwagwiritsidwa ntchito pazinthu zina (monga utoto wosungunuka m'madzi ndi zamkati zamapepala) monga fungicides.
3. Ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito polimbana ndi matenda a matumbo.
4. Furazolidone, monga fungicide, ali ndi antibacterial yotakata.Mabakiteriya omwe amatengeka kwambiri ndi Escherichia coli, Bacillus anthracis, paratyphoid rod, Shigella, ndi Klebsiella pneumoniae.Salmonella typhi imakhudzidwanso ndi izo.Amagwiritsidwa ntchito makamaka pochiza matenda omwe amayamba chifukwa cha kamwazi, enteritis, ndi kolera.Angagwiritsidwenso ntchito pochiza typhoid, paratyphoid, giardiasis, ndi trichomoniasis.Kuphatikiza ndi mankhwala odana ndi asidi angagwiritsidwe ntchito pochiza kutupa kwa m'mimba kwa Helicobacter pylori.Katundu: ufa wachikasu kapena ufa wa crystalline, wopanda fungo, woyamba wopanda pake ndiyeno umakhala wowawa pang'ono;kwambiri pang'ono sungunuka m'madzi ndi Mowa;sungunuka pang'ono mu chloroform ndi wosasungunuka mu ether, sungunuka mu dimethylformamide ndi nitromethane.Mpweya: 255 mpaka 259 °C.Kuwola pamene kupasuka.
Furazolidone ntchito m`mimba matenda ndi vaginitis.Amagwiritsidwa ntchito makamaka m'mayiko omwe akutukuka kumene kuti athetse matenda otsegula m'mimba a etiology yosiyana, koma si mankhwala osankhidwa ngati tizilombo toyambitsa matenda tadziwika.Kugwiritsiridwa ntchito ngati wothandizira wachiwiri mu giardiasis komanso monga gawo la mankhwala osokoneza bongo ambiri mu matenda a Helicobacter adalimbikitsidwa.
3 - [(5-Nitrofurylidene) amino] -2-oxazolidinone (Furoxone) imapezeka ngati ufa wachikasu wa crystalline ndi zowawa zowawa.Sizisungunuka m'madzi kapena mowa.Furazolidone imakhala ndi mabakiteriya olimbana ndi tizilombo toyambitsa matenda a m'mimba, kuphatikizapo S. aureus, E. coli, Salmonella, Shigella, Proteus spp., Enterobacter, ndi Vibrio cholerae. Imagwiranso ntchito motsutsana ndi protozoan Giardia lamblia.Amalangizidwa pakamwa pochiza matenda otsekula m'mimba a bakiteriya kapena protozoal omwe amayamba chifukwa cha tizilombo toyambitsa matenda.Mlingo wamba wamkulu ndi 100 mg kanayi pa tsiku.
Kachigawo kakang'ono kokha ka pakamwa kutumikiridwa mlingo wa furazolidoneis odzipereka.Pafupifupi 5% ya mlingo wapakamwa umapezeka mumkodzo mu mawonekedwe a metabolites angapo. Kusokonezeka kwa m'mimba kwanenedwa ndi kugwiritsidwa ntchito kwake. Mowa uyenera kupewedwa pamene furazolidone ikugwiritsidwa ntchito chifukwa mankhwalawa amatha kuletsa aldehyde dehydrogenase.
