Zogulitsa

Islet amyloid polypeptide (IAPP; yomwe imadziwikanso kuti amylin) ndiyomwe imayambitsa mapangidwe a islet amyloid mumtundu wa 2 shuga, ndipo kawopsedwe ka IAPP kakukhululukidwa kuti amathandizira kutayika kwa β-cell misa yokhudzana ndi magawo omaliza a matenda a shuga a 2.Mapangidwe a Islet amyloid athanso kukhala ndi gawo pakulephera kwa graft pambuyo pa kumuika.IAPP imapangidwa ngati prohormone, pro-islet amyloid polypeptide (proIAPP), ndikusinthidwa muzinthu zobisika za pancreatic β-cell.Mitundu yosinthidwa pang'ono ya proIAPP imapezeka mu ma depositi a amyloid;chodziwika kwambiri ndi 48-residue intermediate, proIAPP(1-48), yomwe imaphatikizapo N-terminal pro-extension, koma yomwe yakonzedwa bwino pa C-terminus.Kukonzekera kosakwanira kungathandize kupanga mapangidwe a islet amyloid mwa kulimbikitsa kuyanjana ndi sulfate proteoglycans ya extracellular matrix, yomwe imalimbikitsa mapangidwe amyloid.Timasonyeza kuti asidi fuchsin (3-(1-(4-amino-3-methyl-5-sulphonatophenyl) -1-(4-amino-3-sulphonatophenyl)methylene)cyclohexa-1,4-dienesulphonic acid), yosavuta. sulfonated triphenyl methyl derivative, ndi choletsa champhamvu cha mapangidwe amyloid ndi proIAPP(1-48) yapakatikati.Chovuta kwambiri chotengera triphenyl methane chochokera ku FCF yobiriwira mwachangu {ethyl--[4--[[4-ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl)methylidene]-1-cyclohexa -2,5-dienylidene]-[(3-sulfophenyl)methyl]azanium} imalepheretsanso mapangidwe a amyloid ndi IAPP ndi proIAPP processing intermediate.Mankhwala onsewa amalepheretsa mapangidwe a amyloid ndi zosakaniza za proIAPP zapakatikati ndi mtundu wa glycosaminoglycan heparan sulfate.Acid fuchsin imalepheretsanso mapangidwe a glycosaminoglycan-mediated amyloid ndi IAPP yokhwima.Kukhoza kulepheretsa mapangidwe a amyloid sikuti kumangochitika chifukwa cha mankhwala omwe ali ndi sulfonated, popeza sulfonated inhibitor ya amyloid-β, tramiprosate, si inhibitor ya mapangidwe a amyloid ndi proIAPP (1-48).