Dirhodium tetraacetate CAS: 15956-28-2 99% Makristasi obiriwira akuda
| Nambala ya Catalog | XD90641 |
| Dzina lazogulitsa | Dirhodium tetraacetate |
| CAS | 15956-28-2 |
| Molecular Formula | C8H12O8Rh2 |
| Kulemera kwa Maselo | 441.987 |
| Zambiri Zosungira | Wozungulira |
| Harmonize Tariff Code | 28439000 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Makristasi obiriwira-wakuda |
| Kuyesa | 99% |
The N7/O6 equatorial kumanga mogwirizana wa antitumor yogwira complex Rh(2)(OAc)(4)(H(2)O)(2) (OAc(-) = CH(3)CO(2)(-)) ndi DNA fragment d(GpG) zatsimikiziridwa momveka bwino ndi mawonekedwe a NMR.M'mbuyomu X-ray crystallographic kutsimikiza kwa mutu-to-mutu (HH) ndi mutu-to-mchira (HT) adducts a dirhodium tetraacetate ndi 9-ethylguanine (9-EtGH) anavumbula mlatho zomwe sizinachitikepo n'kale lonse N7/O6 guanine nucleobases amene amayenda Rh - Rh mgwirizano.Kusapezeka kwa protonation ya N7 pa pH yotsika komanso kuwonjezeka kodziwika kwa acidity ya N1-H (pK(a) pafupifupi 5.7 poyerekeza ndi 8.5 ya ma platinamu omangika a N7 okha), malinga ndi kudalira kwa pH kwa purine H8 (1). ) H NMR resonances za Rh(2)(OAc)(2)(9-EtG)(2) ndi Rh(2)(OAc)(2-)[d(GpG)],zikugwirizana ndi bidentate N7/O6 kumanga ma guanine nucleobases.Mitengo ya pK(a) yoyerekezeredwa ya N1-H (de) protonation, kuchokera ku maphunziro odalira pH a C6 ndi C2 (13)C NMR resonances kwa Rh(2)(OAc)(2)(9-EtG)( 2) ma isomers, amagwirizana ndi t hose yochokera ku H8 (1) H NMR resonance titrations.Kuyerekeza kwa (13)C NMR resonances ya C6 ndi C2 ya dirhodium adducts Rh(2)(OAc)(2)(9-EtG)(2) ndi Rh(2)(OAc)(2)[d(GpG) )] ndi ma resonances ofanana a ligand osamangika [pa pH 7.0 ya 9-EtGH ndi pH 8.0 ya d (GpG)], amasonyeza kusintha kwakukulu kwa Deltadelta pafupifupi 11.0 ndi 6.0 ppm kwa C6 ndi C2, motsatira;masinthidwe otsirizawa akuwonetsa zotsatira za O6 kumangirira ku dirhodium centers ndi kuwonjezereka kotsatira kwa acidity ya N1-H.Mapiri amphamvu kwambiri a H8/H8 ROE mu 2D ROESY NMR sipekitiramu ya Rh(2)(OAc)(2)[d(GpG)] amawonetsa kutengera mutu ndi mutu kwa maziko a guanine.Ma Rh(2)(OAc)(2)[d(GpG)] adduct amaonetsa ma conformers awiri akumanja, HH1 R ndi HH2 R, ndi HH1 R kukhala yochuluka kuwirikiza katatu kuposa HH2 R yachilendo. Zowonjezera zinawonetsa kukana kwa mphete za shuga za 5'-G ku C3'-endo (N-mtundu), kusungidwa kwa C2'-endo (S-type) conformation ya 3'-G sugar ring gs, ndi anti orientation ma glycosyl bonds.Mawonekedwe a Rh(2)(OAc)(2))[d(GpG)] pogwiritsa ntchito mawonekedwe a NMR ndi ofanana kwambiri ndi a cis-[Pt(NH(3))(2)))[d( GpG)]] ndikutsimikizira maphunziro a mamolekyu.
