Zogulitsa

Zinthu zachilengedwe, monga macronutrient kapangidwe kazakudya, zimatha kukhala ndi chiwopsezo chachikulu cha matenda a shuga ndi metabolic syndrome.Mu kafukufuku wapano tikuwonetsa momwe chakudya chimodzi chosavuta - leucine - chingasinthire kukana kwa insulini pochita zinthu zingapo komanso magawo angapo a metabolism.Mbewa zinayikidwa pazakudya zabwinobwino kapena zonenepa kwambiri (HFD).Zakudya za leucine zinawonjezeredwa kuwirikiza pa madzi akumwa.mRNA, mapuloteni ndi mbiri yathunthu ya metabolomic adawunikidwa m'maselo akuluakulu a insulin komanso seramu, ndipo amalumikizidwa ndi kusintha kwa glucose homeostasis ndi signature ya insulin.Pambuyo pa masabata a 8 pa HFD, mbewa zinayamba kunenepa kwambiri, chiwindi chamafuta, kusintha kotupa kwa minofu ya adipose ndi insulin kukana pamlingo wa IRS-1 phosphorylation, komanso kusintha kwa metabolites ya amino acid metabolites, TCA cycle intermediates, glucose ndi cholesterol metabolites. , ndi mafuta acids mu chiwindi, minofu, mafuta ndi seramu.Kuchulukirachulukira kwa leucine yazakudya kunachepetsa zovuta zambiri za metabolite ndikupangitsa kusintha kwakukulu pakulolera kwa shuga komanso kuwonetsa insulin popanda kusintha madyedwe kapena kunenepa.Kuwonjezeka kwa leucine yazakudya kunalumikizidwanso ndi kuchepa kwa hepatic steatosis komanso kuchepa kwa kutupa kwa minofu ya adipose.Zosinthazi zidachitika ngakhale kuchuluka kwa phosphorylation ya insulin-stimulated ya p70S6 kinase kuwonetsa kutsegulira kwa mTOR, chinthu chomwe nthawi zambiri chimakhudzana ndi kukana insulini.Deta iyi ikuwonetsa kuti kusintha pang'ono m'chinthu chimodzi cha chilengedwe / chopatsa thanzi kumatha kusintha njira zingapo zama metabolic ndi ma signature ndikusintha HFD induced metabolic syndrome pochita pamlingo wokhazikika pamatenda angapo.Deta iyi ikuwonetsanso kuti kuwonjezereka kwa leucine yazakudya kungapereke chothandizira pakuwongolera kukana insulini yokhudzana ndi kunenepa kwambiri.