Zogulitsa

Kuchiza kwa ma cell a mammalian ndi mankhwala a chemotherapeutic kungayambitse kusokonezeka kwa maiwe a nucleotide.Kuyang'anira zosokoneza izi m'ma cell chotupa otukuka kuchokera kwa anthu ndikothandiza pakuwunika momwe mankhwalawa amagwirira ntchito komanso kumvetsetsa bwino momwe mankhwalawa amagwirira ntchito.Mu phunziro ili, magulu atatu a mankhwala a chemotherapeutic omwe ali ndi njira zosiyanasiyana zogwirira ntchito anagwiritsidwa ntchito popanga ma cell opangidwa ndi mankhwala.LC-based targeted metabolomics kusanthula kwa ma nucleotides m'maselo a gulu lolamulira ndi gulu la mankhwala osokoneza bongo linachitidwa.Njira zingapo zopangira deta zinaphatikizidwa kuti zizindikiritse zozindikiritsa zomwe zingagwirizane ndi momwe mankhwala amagwiritsidwira ntchito, kuphatikizapo kusanthula kwa njira imodzi ya kusiyanasiyana, kusanthula chigawo chachikulu, ndi ma curve ogwiritsira ntchito olandila.Chochititsa chidwi, maselo otupa a gulu lolamulira ndi magulu omwe amathandizidwa ndi mankhwala amatha kusiyanitsa wina ndi mzake, ndipo mitundu ingapo idadziwika kuti potentia l biomarkers, monga ATP, GMP, ndi UDP kwa othandizira antimetabolite, ATP, GMP, ndi CTP. kwa othandizira owononga DNA, komanso GMP, ATP, UDP, ndi GDP kwa othandizira a mitotic spindle.Kutsimikizira kwina kwa ma biomarker omwe angathe kuchitidwa kunachitika pogwiritsa ntchito njira yolumikizira wolandila.Poganizira dera lawo lofananira pansi pa phirilo, lomwe linali lalikulu kuposa 0.9, tinganene kuti GMP ndi ATP ndizomwe zingatheke kwambiri pamankhwala owononga DNA, komanso GMP, ATP, ndi UDP pamagulu awiri ena a mankhwala.Njira yocheperako ya nucleotide iyi siyingathe kusiyanitsa kwathunthu njira za mankhwala asanu ndi anayi, koma imapereka umboni woyambirira wa gawo la pharmacemetabolomics pakukula kwamankhwala kwamankhwala osachepera.