Zogulitsa

Cardioprotectant: Creatine phosphate ndi chinthu chofunikira kwambiri chopatsa mphamvu pakukanika kwa minofu ndi metabolism.Ndilo mphamvu yamankhwala yosungiramo minofu yosalala ndi minofu yosalala, ndipo imagwiritsidwa ntchito pokonzanso ATP.Phosphocreatinedisodium ndi mawonekedwe ake amankhwala.Sodium Creatine Phosphate, mankhwala dzina N- [imino(phosphono) methyl]-N-methylglycine disodium mchere, ndi cardioprotective agent yomwe inayambika ndi Italy Ouhui Pharmaceutical Factory mu 1992. Fomu ya phosphocreatine imagwira ntchito zosiyanasiyana zofunika pa thupi, ndipo imagwiritsidwa ntchito kwambiri kuteteza myocardial kwa odwala mtima ischemia kapena pamtima Chemicalbook opaleshoni, komanso zochizira matenda amtima monga kulephera mtima, myocardial infarction ndi arrhythmia.Ikhoza kupititsa patsogolo ntchito ya mtima ndi kusinthasintha kwa mtima kwa odwala omwe ali ndi ischemic cardiomyopathy.Iwo sangakhoze kokha kupereka mphamvu kwa maselo m`mnyewa wamtima pamene akudwala ischemia ndi hypoxia, komanso kuteteza m`mnyewa wamtima cell nembanemba ku kuukira mpweya wopanda ankafuna kusintha zinthu mopitirira ndi zinthu zina zoipa, zimene zingakhudze mtima ntchito.Kutetezedwa kwa myocardial kwa odwala omwe ali ndi matenda osakwanira a valvular kumapindulitsa pambuyo pa opaleshoni kuchira kwa mtima kwa odwala omwe ali ndi vuto la valvular.Kugwiritsa ntchito bwino kuchiza kuwonongeka kwa myocardial pambuyo pa neonatal asphyxia kumatha kusintha kwambiri michere ya myocardial ndi electrocardiogram, ndipo kumakhala ndi machiritso abwino komanso chitetezo.

Makhalidwe ogwirira ntchito Izi ndizomwe zimasungira mphamvu zamagetsi zamtima ndi chigoba, ndipo zimagwiritsidwa ntchito pokonzanso ATP, kupereka mphamvu pakupanga kwa actomyosin, ndipo imagwira ntchito yofunika kwambiri pakupanga mphamvu ya metabolism ya minofu.Kusakwanira kwa mphamvu zamagetsi ndizofunikira kwambiri pakupanga ndi chitukuko cha kuvulala kwa myocardial cell.

1. Imateteza kwambiri ntchito ya ischemic myocardial systolic, yomwe imatha kubwezeretsanso mgwirizano ndikuchepetsa kuthamanga kwa magazi a diastolic.

2. Sungani zomwe zili mu adenosine triphosphate ndi creatine phosphate m'maselo, ndipo Chemicalbook imasunga mphamvu ya myocardial mphamvu.

3. Chepetsani kutayika kwa creatine kinase ndikuchepetsa kuwonongeka kwa nembanemba ya cell.

4. Ili ndi anti-peroxidation properties.

5. Kupititsa patsogolo microcirculation ya myocardial.Chifukwa cha kukhalapo kwa ma phosphate amphamvu kwambiri m'mamolekyu a creatine phosphate, zomangira za phosphate zamphamvu zimatha kusintha mwachindunji ADP kukhala ATP mothandizidwa ndi creatine phosphate, ndikupatsanso mphamvu thupi kuti lichitepo kanthu nthawi yomweyo.Monga chopangira chapakatikati cha glycolysis, sodium fructose diphosphate iyenera kuchitapo kanthu mwanjira ya anaerobic metabolism.

njira yopangira:

1 Pogwiritsa ntchito dibenzyl phosphate ngati zopangira, zomwe ndi oxalyl chloride kuti mupeze dibenzyl oxyphosphoryl chloride,

2 Pansi pa zochita za triethylamine, dibenzyloxyphosphoryl creatine ethyl ester analandira ndi anachita ndi creatine ethyl ester hydrochloride ndi cyclized kuti dibenzyloxyphosphoryl creatinine,

3. Pambuyo pa palladium mpweya catalyzed hydrogenolysis kuti debenzylate, anachita ndi sodium hydroxide kupeza disodium creatinine mankwala,

4 ndi hydrolyzed ku 1 pansi pa zochita za sodium hydroxide.

Ntchito: Ndi oyenera kuteteza matenda a m`mnyewa wamtima kagayidwe mu m`mnyewa wamtima ischemia.

Zoyipa, contraindications ndi zotsatira za mankhwala: amene matupi awo sagwirizana zigawo zikuluzikulu za mankhwalawa ndi zoletsedwa;omwe ali ndi vuto la aimpso osatha amaletsedwa kugwiritsa ntchito Mlingo waukulu (5-10g/d).Jakisoni wothamanga m'mitsempha wopitilira 1g angayambitse kuchepa kwa kuthamanga kwa magazi.Kuwongolera mlingo waukulu kumabweretsa kudya kwa phosphate wambiri, zomwe zingakhudze kashiamu kagayidwe kachakudya ndi katulutsidwe ka mahomoni omwe amayang'anira homeostasis, zomwe zimakhudza aimpso ndi purine metabolism.