Zogulitsa

Cystic fibrosis ndi vuto la majini momwe ntchofu zachilendo m'mapapu zimayenderana ndi kutengeka ndi matenda osatha.Kuwonjezeka kwa m'mapapo ndi pamene zizindikiro za matenda zimakhala zovuta kwambiri.Maantibayotiki ndi gawo lofunikira pochiza kuchulukirachulukira ndipo maantibayotiki omwe amakokedwa atha kugwiritsidwa ntchito payekha kapena molumikizana ndi maantibayotiki amkamwa kuti achuluke kwambiri kapena kudzera m'mitsempha yamatenda oopsa kwambiri.Maantibayotiki okoka mpweya samayambitsa zovuta zomwe zimafanana ndi maantibayotiki olowera m'mitsempha ndipo amatha kutsimikizira njira ina mwa anthu omwe alibe mwayi wopita ku mitsempha. sukulu kapena ntchito ndikuwongolera kupulumuka kwawo kwa nthawi yayitali.Tinafufuza ClinicalTrials.gov ndi Australia ndi New Zealand Clinical Trials Registry kuti tiyesetse.Tsiku lofufuzira komaliza: 15 Marichi 2012Tidasakanso Regista ya Mayesero a Cystic Fibrosis ya Cochrane Cystic Fibrosis G.Tsiku lofufuza komaliza: 01 June 2012. Mayesero olamulidwa mwachisawawa mwa anthu omwe ali ndi cystic fibrosis ndi kuwonjezereka kwa pulmonary omwe chithandizo ndi maantibayotiki opumira amafananizidwa ndi placebo, mankhwala ochiritsira kapena mankhwala ena opopera pakati pa sabata imodzi ndi zinayi. mayesero oyenerera osankhidwa, adayesa kuopsa kwa tsankho mu mayesero aliwonse ndi deta yotengedwa.Olemba a mayesero omwe adaphatikizidwa adalumikizidwa kuti adziwe zambiri.Mayesero asanu ndi limodzi ndi anthu a 208 adaphatikizidwa mu ndemanga.Mayesero anali osagwirizana pakupanga ndi kulowererapo (komabe, zonse zidalipo zoyeserera poyerekeza ndi ma intravenous antibiotic regimens).Chiwopsezo cha kukondera chinali chovuta kuwunika m'mayesero ambiri.Zotsatira sizinafotokozedwe mokwanira ndipo deta yochepa yokha inalipo kuti ifufuzidwe.Mayesero anayi adawonetsa zotsatira zina pakukakamiza kupuma kwa mphindi imodzi ndipo sanapeze kusiyana kwakukulu pakati pa maantibayotiki omwe amalowetsedwa ndi kuyerekezera kwa mwana.M'mayesero awiriwa pogwiritsa ntchito 300 mg wa tobramycin wokokedwa, kusintha kwa voliyumu yokakamiza yopuma pamphindi imodzi kunali kofanana ndi tobramycin yolowetsa mtsempha;ndipo mu mayesero amodzi nthawi mpaka kuwonjezereka kwina sikunali kosiyana.Palibe zotsatira zoyipa zomwe zidanenedwa.Pali umboni wochepa wothandiza kwambiri woweruza mphamvu ya maantibayotiki okometsedwa pochiza kuwonjezereka kwa pulmonary mwa anthu omwe ali ndi cystic fibrosis.Mayesero ophatikizidwa analibe mphamvu zokwanira kukwaniritsa zolinga zawo.Motero, sitingathe kusonyeza ngati chithandizo chimodzi chinali chapamwamba kuposa china kapena ayi.Kafukufuku wowonjezereka akufunika kuti adziwe ngati tobramycin atakokedwa angagwiritsidwe ntchito ngati m'malo mwa tobramycin wolowetsa m'mitsempha pazovuta zina zam'mapapo.