Bisbenzimide H33342 Cas: 23491-52-3 Yellow powder
| Nambala ya Catalog | XD90522 |
| Dzina lazogulitsa | Bisbenzimide H33342 |
| CAS | 23491-52-3 |
| Molecular Formula | C27H28N6O·3HCl |
| Kulemera kwa Maselo | 561.93 |
| Zambiri Zosungira | -15 mpaka -20 ° C |
| Harmonize Tariff Code | 32129000 |
Mafotokozedwe a Zamalonda
| Maonekedwe | Yellow powder |
| Kuyesa | 99% |
Bakiteriya metabolite ya m'mimba ya ginseng protopanaxadiol saponin, 20-O-(β-D-glucopyranosyl) -20(S) -protopanaxadiol (compound K), yanenedwa kuti imapangitsa apoptosis m'maselo osiyanasiyana a khansa.Komabe, njira zenizeni zomwe zimapangitsidwa ndi gulu K m'maselo a hepatocellular carcinoma (HCC) sizikudziwika.Kuti tiwone momwe angagwiritsire ntchito ma apoptotic, tidafufuza za anticancer pagulu K mu MHCC97-H.Kuyesa kwa MTT kunawonetsa kuti chigawo K chinalepheretsa kuchuluka kwa maselo a MHCC97-H omwe ali ndi poizoni wochepa kwambiri m'maselo a hepatoma.Kupitilira kwa ma cell ndi kuyatsa kwa ma cell kunawonetsa kuwonjezeka kwa gawo la apoptotic sub-G1.Kuchiza kwa MHCC97-H yokhala ndi K kumapangitsanso kuchepetsa kuthekera kwa membrane wa mitochondrial (Δψm) ndi kuwonongeka kwa DNA.Kafukufuku wowonjezereka adawonetsa kuti gulu la K limayang'anira chiŵerengero cha Fas, FasL, Bax / Bcl-2 ndi kuchepetsa pro-caspase-9, pro-caspase-3 m'njira yodalira mlingo, komanso inalepheretsa Akt phosphorylation.Zotsatirazi zikusonyeza kuti chigawo K chimalepheretsa kukula kwa maselo ndipo chimapangitsa apoptosis m'maselo a MHCC97-H kupyolera mu Fas- ndi mitochondria-mediated caspase-based pathways m'maselo aumunthu a HCC.
