Zogulitsa

Mankhwala ambiri oletsa khansa amalephera kuthetsa zotupa, zomwe zimayambitsa kukula kwa mankhwala osakanizidwa ndi matenda komanso kubwereranso kwa matenda.Chizindikiro cha Hedgehog chimagwira ntchito yofunika kwambiri pakukula kwa embryonic, komanso kumakhudzidwa ndi kukula kwa khansa, kupita patsogolo, ndi metastasis.The Hedgehog Receptor Patched (Ptc) ndi mtundu wa chandamale cha Hedgehog chomwe chimachulukitsidwa kwambiri m'maselo ambiri a khansa.Apa, tikuwonetsa kulumikizana pakati pa Ptc ndi kukana mankhwala amphamvu, ndikupereka chidziwitso chatsopano pa ntchito ya Ptc.Ptc imachotsedwa ku nembanemba ya plasma ikalumikizana ndi ligand Hedgehog, kapena pochiza ma cell omwe ali ndi Hedgehog signing antagonist cyclopamine.M'zochitika zonsezi, pambuyo poyamwitsa maselo ndi doxorubicin, chemotherapeutic agent yomwe imagwiritsidwa ntchito poyang'anira khansa yobwerezabwereza, tinawona kulepheretsa kwa doxorubicin kuchokera ku Hedgehog-kuyankha fibroblasts, ndi kuwonjezeka kwa doxorubicin kudzikundikira mu khansa ziwiri zosiyana. ma cell omwe amadziwika kuti amawonetsa kuchuluka kwazinthu zozindikiritsa za Hedgehog.Pogwiritsa ntchito mawonekedwe a heterologous, tidawonetsa mwamphamvu kuti kufotokozera kwa Ptc yamunthu kumapangitsa kukana kuletsa kukula ndi mankhwala angapo omwe chemotherapeutic agents monga doxorubicin, methotrexate, temozolomide, ndi 5-fluorouracil.Kukana kwa doxorubicin kumagwirizana ndi ntchito ya Ptc, monga momwe ziwonetsedwera pogwiritsa ntchito kusintha kwa odwala a Gorlin's syndrome momwe Ptc-mediated effect pa chizindikiro cha Hedgehog imatayika.Zotsatira zathu zikuwonetsa kuti Ptc imakhudzidwa ndi kutha kwa mankhwala osokoneza bongo komanso kukana kwamankhwala ambiri, ndipo zikuwonetsa kuti Ptc imathandizira kukana kwa ma cell a khansa.