Zogulitsa

Niacin (nicotinic acid) ngati monotherapy imatha kuchepetsa chiwopsezo cha matenda amtima, koma momwe amagwirira ntchito amakhalabe mkangano, ndipo mwina sangadalire pakusintha kwa lipid.Niacin posachedwapa yasonyezedwa kuti imathandizira endothelial ntchito ndi kusinthika kwa mitsempha, popanda kuwongolera dyslipidemia, m'mitundu ya makoswe a kuvulala kwa mitsempha ndi matenda a metabolic.Monga kalambulabwalo wa biosynthetic wa NAD(+), niacin imatha kudzetsa mapindu am'mitsemphawa kudzera mu mayankho apakati a NAD(+), a sirtuin (SIRT).Kapenanso, niacin ikhoza kuchitapo kanthu kudzera mu cholandirira chake, GPR109A, kulimbikitsa endothelial ntchito, ngakhale ma cell a endothelial samadziwika kuti amawonetsa cholandilira ichi.Tinkaganiza kuti niacin imapangitsa kuti maselo a endothelial azigwira ntchito bwino panthawi yomwe ali ndi lipotoxic ndipo tinayesetsa kudziwa zomwe zingatheke. kutsika kwa niacin (10 μM), kapena nicotinamide mononucleotide (NMN) (1 μM), kalambulabwalo wachindunji wa NAD(+).Ngakhale kuti niacin ndi NMN zonse zimathandizira kupanga machubu a HMVEC panthawi yodzaza palmitate, NMN yokhayo inakulitsa ma cell NAD(+) ndi SIRT1 ntchito.Tidawonanso kuti HMVEC ikuwonetsa GRP109A.Kutsegula kwa cholandilira ichi chokhala ndi acifran kapena MK-1903 chomwe chinapangitsanso kusintha kwa niacin pakupanga machubu a HMVEC, pomwe GPR109A siRNA imachepetsa mphamvu ya niacin. +) biosynthesis ndi SIRT1 activation, koma kudzera mwa niacin receptor activation.