Zogulitsa

NADPH oxidase ndi gulu la michere yomwe imapanga mitundu ya okosijeni (ROS).NOX1 (NADPH oxidase 1) ndi NOX2 oxidase ndiye magwero akuluakulu a ROS mu khoma la mitsempha mumikhalidwe monga kuthamanga kwa magazi, hypercholesterolemia, shuga ndi ukalamba, motero ndizofunikira kwambiri pakupsinjika kwa okosijeni, kulephera kwa endothelial ndi kutupa kwa mitsempha yomwe imayambitsa. kukonzanso kwa mitsempha ndi atherogenesis.Mu Ndemanga iyi, timapititsa patsogolo lingaliro loti poyerekeza ndi kugwiritsa ntchito antioxidants wamba, kuletsa NOX1 ndi NOX2 oxidases ndi njira yabwino kwambiri yothanirana ndi kupsinjika kwa okosijeni.Timalongosola mwachidule zoletsa za NADPH oxidase inhibitors zomwe zimadziwika komanso zomwe zikubwera.Kuphatikiza apo, tikuwonetsa gawo lofunikira la gawo loyang'anira oxidase la NADPH, p47phox, pakuchita ma vascular NOX1 ndi NOX2 oxidases, ndikuwonetsa momwe kumvetsetsa bwino momwe ma cell amagwirira ntchito kumathandizira kupanga mankhwala osankhidwa a isoform kuti apewe. kapena kuchiza matenda a cardiova scular.