Zogulitsa

Ma polima burashi zigawo zochokera ku chipika copolymers a poly(oligo(ethylene glycol) methacrylate) (POEGMA) ndi poly(glycidyl methacrylate) (PGMA) anapangidwa pa zowotcha pakachitsulo ndi activators kwaiye ndi ma elekitironi kusamutsa atomu kusamutsa kwakukulu polymerization (AGET ATRP).Mitundu yosiyanasiyana ya biomolecule imatha kulumikizidwa ku zigawo za burashi izi pochita magulu a PGMA epoxide okhala ndi magulu amino mu biomolecule, pomwe POEGMA, yomwe imakana kutsatsa kwa protein yosadziwika, imapereka malo oletsa kufooketsa.Pamwamba pamakhala mawonekedwe olumikizana ndi madzi, ellipsometry, ndi Fourier transform infrared spectroscopy (FTIR) kutsimikizira momwe kusinthaku kukuyendera.Kugawikana kwa magawo a midadada ya copolymer m'magawo adawonedwa ndi AFM.Zotsatira za zinthu zapamtunda pakulumikizana kwa mapuloteni zidafufuzidwa pogwiritsa ntchito njira zama radiolabeling.Zinawonetsedwa kuti zokhala ndi zigawo za POEGMA zinali zosagwirizana ndi mapuloteni, pomwe kuchuluka kwa mapuloteni omwe amalumikizana ndi diblock copolymer mosinthidwa malo akuwonjezeka ndi kuchuluka kwa PGMA wosanjikiza.Ntchito ya lysozyme yolumikizidwa pamwamba ingathenso kuwongoleredwa posintha makulidwe a wosanjikiza wa copolymer.Pamene biotin idalumikizidwa ku block copolymer grafts, pamwamba pake idakhalabe yosagwirizana ndi mapuloteni osakhazikika koma adawonetsa kumangika kwa avidin.Katunduyu, ndiye kuti, kuchuluka kolamuliridwa bwino ndi zochita za ma biomolecules ophatikizana komanso kutsimikizika kwa kugwirizana ndi chandamale ma biomolecules atha kugwiritsidwa ntchito kuti apititse patsogolo kuchuluka kwa ma signal-to-phokoso pakugwiritsa ntchito sensa.Nthawi zambiri, malo oterowo atha kukhala othandiza ngati zinthu zozindikiritsa zamoyo zamtundu wapamwamba kwambiri wama biomaterials.