Zogulitsa

Magulu atatu a anyani akuluakulu amphongo a cynomolgus (Macaca fascicularis) adawonekera ku 200 micrograms / m3 ammonium hexachloroplatinate [(NH4) 2PtCl6], 200 micrograms (NH4) 2PtCl6 nthawi yomweyo ndi 1 ppm ozone (O3), kapena ku O3 1 yokha.Nyamazo zinkawonekera pokoka mpweya kwa maola 6 patsiku, masiku asanu pa sabata kwa masabata 12.Mapangidwe oyeserawo adaphatikizanso kuwunika kwa methacholine preexposure ndi Na2PtCl6 bronchoprovocation challenge, Na2PtCl6 threshold skin test, and sera for analysis of antibodies.Masabata awiri pambuyo pa kuwonekera kwa 12-wk, zizindikiro zomwezi zidawunikidwanso.Ntchito yoyambira m'mapapo mwanga sinakhudzidwe kwambiri ndi machitidwe owonetsera;komabe, kuphatikiza kukhudzana ndi O3 ndi (NH4)2PtCl6 kunachepetsa kwambiri mchere wa platinamu (Pt) ndi methacholine wofunikira kuti awonjezere kukana kwa pulmonary flow resistance (RL) 200% (EC200 RL).Kuwonetsedwa kwa ozoni kapena Pt kokha sikunakhudze kwambiri magawowa.Magulu a Platinum ndi methacholine EC200 RL anali ogwirizana kwambiri kwa magulu onse a Pt atawonekera.Deta iyi ikuwonetsa kuti kukhudzana kwa O3 ndi Pt kumawonjezeka kwambiri (Pt) komanso osakhazikika (methacholine) bronchial hyperreactivity nthawi zambiri kusiyana ndi kukhudzana ndi O3 kapena Pt mchere wokha.Kuphatikiza kwa O3 kuphatikiza Pt kumawonjezeranso kwambiri kuchuluka kwa mayeso abwino a khungu la Pt poyerekeza ndi magulu ena owonetsa.Mofanana ndi zomwe anthu adakumana nazo, kuyesa kwa radioallergosorbent (RAST) kwa ma antibodies a Pt sikunali kovutirapo ngati kuyezetsa khungu kwachindunji pozindikira anthu omwe sanagwirizane nawo.